Papers acknowledging HEPADIP

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Pamphlet - Hepadip 2nd Annual Meeting 2006

Reviews

Biology of Adipose Tissue

Frayn KN, Langin D, Karpe F. Fatty acid-induced mitochondrial uncoupling in adipocytes is not a promising target for treatment of insulin resistance unless adipocyte oxidative capacity is increased. Diabetologia. 2008 Mar;51(3):394-7. Epub 2007 Dec 21.

Gustafson B, Hammarstedt A, Andersson CX, Smith U. Inflamed Adipose Tissue: A Culprit Underlying the Metabolic Syndrome and Atherosclerosis. Arterioscler Thromb Vasc Biol. 2007 Sep 6; [Epub ahead of print].

Langin D. Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome. Pharmacol Res. 2006 Jun;53(6):482-91. Epub 2006 Mar 27.

Langin D. Control of fatty acid and glycerol release in adipose tissue lipolysis. C R Biol. 2006 Aug;329(8):598-607; discussion 653-5. Epub 2006 Apr 27. Review.

Langin D, Arner P. Importance of TNFalpha and neutral lipases in human adipose tissue lipolysis. Trends Endocrinol Metab. 2006 Oct;17(8):314-320. Epub 2006 Aug 30.

Biology of Liver Tissue

Leclercq IA, Da Silva Morais A, Schroyen B, Van Hul N, Geerts A. Insulin Resistance in hepatocytes and sinusoidal liver cells: mechanisms and consequences. J Hepatol. 2007 Jul;47(1):142-56. Epub 2007 Apr 16.

Mato JM, Lu SC. Role of S-adenosyl-L-methionine in liver health and injury. Hepatology. 2007 May;45(5):1306-12. Review.

Matthiesen R. Methods, algorithms and tools in computational proteomics: A practical point of view. Proteomics. 2007 Aug;7(16):2815-32.

Rodent Studies: The Adipose - Liver Axis

Cariou B, Staels B. FXR: a promising target for the metabolic syndrome? Trends Pharmacol Sci. 2007 May;28(5):236-43.

Cariou B, Staels B. The expanding role of the bile acid receptor FXR in the small intestine. J Hepatol. 2006 Jun;44(6):1213-5.

Caron S, Cariou B, Staels B. FXR: More than a bile acid receptor? Endocrinology. 2006 Sep;147(9):4022-4.

Kuipers F, Stroeve JHM, Caron S, Staels B. Bile acids, farnesoid X receptor, atherosclerosis and metabolic control. Curr Opin Lipidol. 2007 Jun;18(3):289-297.

Sethi JK, Vidal-Puig AJ. Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res. 2007 Jun;48(6):1253-62.

Staels B, Kuipers F. Bile acid sequestrants and the treatment of type 2 diabetes mellitus. Drugs. 2007;67(10):1383-92.

Human Studies: The Adipose - Liver Axis

Adiels M, Olofsson SO, Taskinen MR, Borén J. Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome. Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1225-36.

Frayn KN, Arner P, Yki-Jarvinen H. Fatty acid metabolism in adipose tissue, muscle and liver in health and disease. Essays Biochem. 2006;42:89-103. Review.

Kotronen A, Yki-Jarvinen H. Fatty Liver. A Novel Component of the Metabolic Syndrome. Arterioscler Thromb Vasc Biol. 2007 Aug 9.

Clinical and Genetic Epidemiological Studies

Berentzen T, Sørensen TIA. Effects of intended weight loss on morbidity and mortality: possible explanations of controversial results. Nutr Rev. 2006 Nov;64(11):502-7.

Jakobsen MU, Berentzen T, Sørensen TIA, Overvad K. Abdominal Obesity and Fatty Liver. Epidemiol Rev. 2007;29:77-87. Epub 2007 May 2.

Verrijken A, Francque S, Van Gaal L. The metabolic syndrome and the liver. Acta Gastroenterol Belg. 2008 Jan-Mar;71(1):48-59. PMID: 18396752 [PubMed - in process].



Original Papers

Biology of Adipose Tissue

Andersson CX, Sopasakis VR, Wallerstedt E, Smith U. Insulin antagonizes IL-6 signaling and is anti-inflammatory in 3T3-L1 adipocytes. J Biol Chem. 2007 Mar 30;282(13):9430-5. Epub 2007 Jan 31.

Aouadi M, Jager J, Laurent K, Gonzalez T, Cormont M, Binétruy B, Le Marchand-Brustel Y, Tanti JF, Bost F. p38MAP Kinase activity is required for human primary adipocyte differentiation. FEBS Lett. 2007 Dec 11;581(29):5591-6. Epub 2007 Nov 13.

Bajzová M, Kovaciková M, Vitková M, Klimcaková E, Polak J, Kovacová Z, Viguerie N, Vedral T, Mikulášek L, Sramková P, Srp A, Hejnová J, Langin D, Stich V. Retinol -binding protein 4 expression in visceral and subcutaneous fat in human obesity. Physiol Res. 2007 Nov 30. [Epub ahead of print]

Bertola A, Bonnafous S, Cormont M, Anty R, Tanti JF, Tran A, Le Marchand-Brustel Y, Gual P. Hepatocyte growth factor induces glucose uptake in 3T3-L1 adipocytes through a GAB1/ PI 3-kinase /GLUT4 pathway. J Biol Chem. 2007 Apr;282(14):10325-32. Epub 2007 Feb 6.

Dahlman I, Dicker A, Jiao H, Kere J, Blomqvist L, van Harmelen V, Hoffstedt J, Borch-Johnsen K, Jorgensen T, Hansen T, Pedersen O, Laakso M, Arner P. A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis. Am J Hum Genet. 2007 Jun;80(6):1115-24. Epub 2007 May 2.

Dahlman I, Forsgren M, Sjogren A, Nordstrom EA, Kaaman M, Naslund E, Attersand A, Arner P. Downregulation of Electron Transport Chain Genes in Visceral Adipose Tissue in Type 2 Diabetes Independent of Obesity and Possibly Involving Tumor Necrosis Factor-{alpha}. Diabetes. 2006 Jun;55(6):1792-9.

Henegar C, Tordjman J, Achard V, Lacasa D, Cremer I, Guerre-Millo M, Poitou C, Basdevant A, Stich V, Viguerie N, Langin D, Bedossa P, Zucker JD, Clement K. Adipose tissue transcriptomics signature highlights the pathological relevance of extracellular matrix in human obesity. Genome Biol. 2008 Jan 21;9(1):R14 [Epub ahead of print].

Jager J, Gremeaux T, Cormont M, Le Marchand-Brustel Y, Tanti JF. Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology. 2007 Jan;148(1):241-51. Epub 2006 Oct 12. PMID: 17038556 [PubMed - as supplied by publisher].

Jocken JW, Langin D, Smit E, Saris WH, Valle C, Hul GB, Holm C, Arner P, Blaak EE. Adipose triglyceride lipase and hormone-sensitive lipase protein expression is decreased in the obese insulin-resistant state. J Clin Endocrinol Metab. 2007 Jun;92(6):2292-9. Epub 2007 Mar 13.

Kaaman M, Sparks LM, van Harmelen V, Smith SR, Sjolin E, Dahlman I, Arner P. Strong association between mitochondrial DNA copy number and lipogenesis in human white adipose tissue. Diabetologia. 2007 Sep 19; [Epub ahead of print].

Klimcakova E, Moro C, Mazzucotelli A, Lolmède K, Viguerie N, Galitzky J, Stich V, Langin D. Profiling of adipokines secreted from human subcutaneous adipose tissue in response to PPAR agonists. Biochem. Biophys. Res. Commun. 2007 Jul 6;358(3):897-902.

Langin D, Dicker A, Tavernier G, Hoffstedt J, Mairal A, Ryden M, Arner E, Sicard A, Jenkins CM, Viguerie N, van Harmelen V, Gross RW, Holm C, Arner P. Adipocyte lipases and defect of lipolysis in human obesity. Diabetes. 2005 Nov;54(11):3190-7.

Laurencikiene J, van Harmelen V, Arvidsson Nordstrom E, Dicker A, Blomqvist L, Naslund E, Langin D, Arner P, Ryden M. NF-kappaB is important for TNF-alpha-induced lipolysis in human adipocytes. J Lipid Res. 2007 May;48(5):1069-77.

Lång P, van Harmelen V, Rydén M, Kaaman M, Parini P, Carneheim C, Cassady AI, Hume DA, Andersson G, Arner P. Monomeric tartrate resistant acid phosphatase induces insulin sensitive obesity. PLoS ONE. 2008 Mar 5;3(3):e1713.

Mairal A, Langin D, Arner P, Hoffstedt J. Human adipose triglyceride lipase (PNPLA2) is not regulated by obesity and exhibits low in vitro triglyceride hydrolase activity. Diabetologia. 2006 Jul;49(7):1629-36. Epub 2006 May 10.

Mazzucotelli A, Viguerie N, Tiraby C, Annicotte JS, Mairal A, Klimcakova E, Lepin E, Delmar P, Dejean S, Tavernier G, Lefort C, Hidalgo J, Pineau T, Fajas L, Clement K, Langin D. The transcriptional coactivator peroxisome proliferator activated receptor (PPAR)gamma coactivator-1 alpha and the nuclear receptor PPAR alpha control the expression of glycerol kinase and metabolism genes independently of PPAR gamma activation in human white adipocytes. Diabetes. 2007 Oct;56(10):2467-75. Epub 2007 Jul 23.

Moro C, Klimcakova E, Lolmede K, Berlan M, Lafontan M, Stich V, Bouloumie A, Galitzky J, Arner P, Langin D. Atrial natriuretic peptide inhibits the production of adipokines and cytokines linked to inflammation and insulin resistance in human subcutaneous adipose tissue. Diabetologia. 2007 May;50(5):1038-47. Epub 2007 Feb 23.

Polak J, Moro C, Bessiere D, Hejnova J, Marques MA, Bajzova M, Lafontan M, Crampes F, Berlan M, Stich V. Acute exposure to long-chain fatty acids impairs {alpha}2-adrenergic receptor-mediated antilipolysis in human adipose tissue. J Lipid Res. 2007 Oct;48(10):2236-46. Epub 2007 Jul 11.

Polak J, Moro C, Klimcakova E, Kovacikova M, Bajzova M, Vitkova M, Kovacova Z, Sotornik R, Berlan M, Viguerie N, Langin D, Stich V. The atrial natriuretic peptide- and catecholamine-induced lipolysis and expression of related genes in adipose tissue in hypothyroid and hyperthyroid patients. Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E246-51. Epub 2007 Mar 27.

Ryden M, Jocken J, van Harmelen V, Dicker A, Hoffstedt J, Wiren M, Blomqvist L, Mairal A, Langin D, Blaak EE, Arner P. Comparative Studies of the Role of Hormone Sensitive Lipase and Adipose Triglyceride Lipase in Human Fat Cell Lipolysis. Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1847-55. Epub 2007 Feb 27.

Seale P, Kajimura S, Yang W, Chin S, Rohas LM, Uldry M, Tavernier G, Langin D, Spiegelman BM. Transcriptional Control of Brown Fat Determination by PRDM16. Cell Metab. 2007 Jul;6(1):38-54. PMID: 17618855 [PubMed - in process].

van Harmelen V, Eriksson A, Aström G, Wåhlén K, Näslund E, Karpe F, Frayn K, Olsson T, Andersson J, Rydén M, Arner P. Vascular peptide endothelin-1 links fat accumulation with alterations of visceral adipocyte lipolysis Diabetes. 2008 Feb;57(2):378-86. Epub 2007 Nov 19.

Vitkova M, Klimcakova E, Kovacikova M, Valle C, Moro C, Polak J, Hanacek J, Capel F, Viguerie N, Richterova B, Bajzova M, Hejnova J, Stich V, Langin D. Plasma levels and adipose tissue messenger ribonucleic acid expression of retinol-binding protein 4 are reduced during calorie restriction in obese subjects but are not related to diet-induced changes in insulin sensitivity. J Clin Endocrinol Metab. 2007 Jun;92(6):2330-5. Epub 2007 Apr 3.

Biology of Liver Tissue

Chen H, Xia M, Lin M, Yang H, Kuhlenkamp J, Li T, Sodir NM, Chen YH, Josef-Lenz H, Laird PW, Clarke S, Mato JM, Lu SC. Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterology. 2007 Jul;133(1):207-18. Epub 2007 Apr 11. Erratum in: Gastroenterology. 2007 Nov;133(5):1747.

Martínez-Chantar ML, Vázquez-Chantada M, Ariz U, Martínez N, Varela M, Luka Z, Capdevila A, Rodríguez J, Aransay AM, Matthiesen R, Yang H, Calvisi DF, Esteller M, Fraga M, Lu SC, Wagner C, Mato JM. Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. Hepatology. 2008 Apr;47(4):1191-9.

Omaetxebarria MJ, Elortza F, Rodríguez-Suárez E, Aloria K, Arizmendi JM, Jensen ON, Matthiesen R. Computational approach for identification and characterization of GPI-anchored peptides in proteomics experiments. Proteomics. 2007 Jun;7(12):1951-60.

Ou X, Yang H, Ramani K, Ara AI, Chen H, Mato JM, Lu SC. Inhibition of human betaine-homocysteine methyltransferase expression by S-adenosylmethionine and methylthioadenosine. Biochem J. 2007 Jan 1;401(1):87-96.

Ramani K, Yang H, Xia M, Ara AI, Mato JM, Lu SC. Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta.Hepatology. 2008 Feb;47(2):521-31.

Rodríguez JL, Boukaba A, Sandoval J, Georgieva EI, Latasa MU, García-Trevijano ER, Serviddio G, Nakamura T, Avila MA, Sastre J, Torres L, Mato JM, López-Rodas G. Transcription of the MAT2A gene, coding for methionine adenosyltransferase, is up-regulated by E2F and Sp1 at a chromatin level during proliferation of liver cells.Int J Biochem Cell Biol. 2007;39(4):842-50. Epub 2007 Jan 20.

Rountree CB, Senadheera S, Mato JM, Crooks GM, Lu SC. Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice. Hepatology. 2008 Apr;47(4):1288-97.

Rubio A, Guruceaga E, Vázquez-Chantada M, Sandoval J, Martínez-Cruz LA, Segura V, Sevilla JL, Podhorski A, Corrales FJ, Torres L, Rodríguez M, Aillet F, Ariz U, Arrieta FM, Caballería J, Martín-Duce A, Lu SC, Martínez-Chantar ML, Mato JM. Identification of a gene-pathway associated with non-alcoholic steatohepatitis. J Hepatol. 2007 Apr;46(4):708-18. Epub 2006 Nov 30.

Yang H, Magilnick N, Noureddin M, Mato JM, Lu SC. Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells. J Cell Physiol. 2007 Mar;210(3):766-73.

Yuan JM, Lu SC, Van Den Berg D, Govindarajan S, Zhang ZQ, Mato JM, Yu MC. Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma. Hepatology. 2007 Sep;46(3):749-58.

Rodent Studies: The Adipose - Liver Axis

Cariou B, Bouchaert E, Abdelkarim M, Dumont J, Caron S, Fruchart JC, Burcelin R, Kuipers F, Staels B. FXR-deficiency confers increased susceptibility to torpor. FEBS Lett. 2007 Nov 13;581(27):5191-8. Epub 2007 Oct 12.

Cariou B, van Harmelen K, Duran-Sandoval D, van Dijk TH, Grefhorst A, Abdelkarim M, Caron S, Torpier G, Fruchart JC, Gonzalez FJ, Kuipers F, Staels B. The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice. J Biol Chem. 2006 Apr 21;281(16):11039-49. Epub 2006 Jan 30.

Duran-Sandoval D, Cariou B, Percevault F, Hennuyer N, Grefhorst A, van Dijk TH, Gonzalez FJ, Fruchart JC, Kuipers F, Staels B. The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition. J Biol Chem. 2005 Aug 19;280(33):29971-9. Epub 2005 May 16.

Gray SL, Dalla Nora E, Backlund EC, Manieri M, Virtue S, Noland RC, O'Rahilly S, Cortright RN, Cinti S, Cannon B, Vidal-Puig A. Decreased brown adipocyte recruitment and thermogenic capacity in mice with impaired peroxisome proliferator-activated receptor (P465L PPARgamma) function.Endocrinology. 2006 Dec;147(12):5708-14.

Gray SL, Dalla Nora E, Grosse J, Manieri M, Stoeger T, Medina-Gomez G, Burling K, Wattler S, Russ A, Yeo G, Chatterjee V, O’Rahilly S, Voshol P, Cinti S, Vidal-Puig A. Leptin deficiency unmasks the deleterious effects of impaired PPARγ function (P465L PPARγ) in mice. Diabetes. 2006 Oct;55(10):2669-2677.

Lalloyer F, Vandewalle B, Percevault F, Torpier G, Kerr-Conte J, Oosterveer M, Paumelle R, Fruchart J-C, Kuipers F, Pattou F, Fiévet C, Staels B. Peroxisome Proliferator–Activated Receptor Improves Pancreatic Adaptation to Insulin Resistance in Obese Mice and Reduces Lipotoxicity in Human Islets. Diabetes. 2006 Jun;55:1605-1613.

Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GSH, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A. PPAR gamma 2 Prevents Lipotoxicity by Controlling Adipose Tissue Expandability and Peripheral Lipid Metabolism. PLoS Genetics. 2007 Apr 27;3(4):e64.

Medina-Gomez G, Virtue S, Lelliott C, Boiani R, Campbell M, Christodoulides C, Perrin C, Jimenez-Linan M, Blount M, Dixon J, Zahn D, Thresher RR, Aparicio S, Carlton M, Colledge WH, Kettunen MI, Seppanen-Laakso T, Sethi JK, O'Rahilly S, Brindle K, Cinti S, Oresic M, Burcelin R, Vidal-Puig A. The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform. Diabetes. 2005 Jun;54(6):1706-16.

Murakami T, Walczak R, Caron S, Duhem C, Vidal V, Darteil R, Staels B. The farnesoid X receptor induces fetuin-B gene expression in human hepatocytes. Biochem J. 2007 Jul 27; [Epub ahead of print].

Yetukuri L, Katajamaa M, Medina-Gomez G, Seppänen-Laakso T, Vidal Puig A, Orešič M. Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis. BMC Systems Biology 1, e12 (2007). doi:10.1186/1752-0509-1-12.

Human Studies: The Adipose - Liver Axis

Adiels M, Westerbacka J, Soro-Paavonen A, Häkkinen AM, Vehkavaara S, Caslake MJ, Packard C, Olofsson SO, Yki-Järvinen H, Taskinen MR, Borén J. Acute suppression of VLDL(1) secretion rate by insulin is associated with hepatic fat content and insulin resistance. Diabetologia. 2007 Nov;50(11):2356-65. Epub 2007 Sep 12.

Anty R, Bekri S, Luciani N, Saint-Paul MC, Dahman M, Iannelli A, Amor IB, Staccini-Myx A, Huet PM, Gugenheim J, Sadoul JL, Le Marchand-Brustel Y, Tran A, Gual P. The Inflammatory C-Reactive Protein Is Increased in Both Liver and Adipose Tissue in Severely Obese Patients Independently from Metabolic Syndrome, Type 2 Diabetes, and NASH. Am J Gastroenterol. 2006 Aug;101(8):1824-33. Epub 2006 Jun 22.

Bekri S, Gual P, Anty R, Luciani N, Dahman M, Ramesh B, Iannelli A, Staccini-Myx A, Casanova D, Ben Amor I, Saint-Paul MC, Huet PM, Sadoul JL, Gugenheim J, Srai SK, Tran A, Le Marchand-Brustel Y. Increased Adipose Tissue Expression of Hepcidin in Severe Obesity Is Independent From Diabetes and NASH. Gastroenterology. 2006 Sep;131(3):788-796.

Chong MF, Hodson L, Bickerton AS, Roberts R, Neville M, Karpe F, Frayn KN, Fielding BA. Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding. Am J Clin Nutr. 2008 Apr;87(4):817-23.

Greco D, Kotronen A, Westerbacka J, Puig O, Arkkila P, Kiviluoto T, Laitinen S, Kolak M, Fisher RM, Hamsten A, Auvinen P, Yki-Järvinen H. Gene expression in human NAFLD. Am J Physiol Gastrointest Liver Physiol. 2008 May;294(5):G1281-7. Epub 2008 Apr 3.

Guiducci L, Gronroos T, Jarvisalo MJ, Kiss J, Viljanen A, Naum AG, Viljanen T, Savunen T, Knuuti J, Ferrannini E, Salvadori PA, Nuutila P, Iozzo P. Biodistribution of the fatty acid analogue 18F-FTHA: plasma and tissue partitioning between lipid pools during fasting and hyperinsulinemia. J Nucl Med. 2007 Mar;48(3):455-62.

Guiducci L, Jarvisalo M, Kiss J, Nagren K, Viljanen A, Naum AG, Gastadelli A, Savunen T, Knuuti J, Salvadori PA, Ferrannini E, Nuutila P, Iozzo P. [11C]palmitate kinetics across the splanchnic bed in arterial, portal and hepatic venous plasma during fasting and euglycemic hyperinsulinemia. Nucl Med Biol. 2006 May;33(4):521-8. Epub 2006 May 2.

Hodson L, Bickerton AS, McQuaid SE, Roberts R, Karpe F, Frayn KN, Fielding BA. The contribution of splanchnic fat to VLDL triglyceride is greater in insulin-resistant than insulin-sensitive men and women: studies in the postprandial state. Diabetes. 2007 Oct;56(10):2433-41. Epub 2007 Jun 29.

Iozzo P, Gastaldelli A, Jarvisalo MJ, Kiss J, Borra R, Buzzigoli E, Viljanen A, Naum G, Viljanen T, Oikonen V, Knuuti J, Savunen T, Salvadori PA, Ferrannini E, Nuutila P. 18F-FDG assessment of glucose disposal and production rates during fasting and insulin stimulation: a validation study. J Nucl Med. 2006 Jun;47(6):1016-22.

Iozzo P, Jarvisalo MJ, Kiss J, Borra R, Naum GA, Viljanen A, Viljanen T, Gastaldelli A, Buzzigoli E, Guiducci L, Barsotti E, Savunen T, Knuuti J, Haaparanta-Solin M, Ferrannini E, Nuutila P. Quantification of liver glucose metabolism by positron emission tomography: validation study in pigs. Gastroenterology. 2007 Feb;132(2):531-42. Epub 2006 Dec 21.

Juurinen L, Kotronen A, Granér M, Yki-Järvinen H. Rosiglitazone reduces liver fat and insulin requirements and improves hepatic insulin sensitivity and glycemic control in patients with type 2 diabetes requiring high insulin doses. J Clin Endocrinol Metab. 2008 Jan;93(1):118-24. Epub 2007 Oct 23.

Kankaanpää M, Lehto HR, Pärkkä JP, Komu M, Viljanen A, Ferrannini E, Knuuti J, Nuutila P, Parkkola R, Iozzo P. Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels. J Clin Endocrinol Metab. 2006 Nov;91(11):4689-95. Epub 2006 Aug 22.

Kolak M, Westerbacka J, Velagapudi VR, Wågsäter D, Yetukuri L, Makkonen J, Rissanen A, Häkkinen A-M, Lindell M, Bergholm R, Hamsten A, Eriksson P, Fisher RM, Orešic M, Yki-Järvinen H. Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat independent of obesity. Diabetes. 2007 Aug;56(8):1960-8. Epub 2007 Jul 9. PMID: 17620421 [PubMed - as supplied by publisher].

Kotronen A, Juurinen L, Hakkarainen A, Westerbacka J, Cornér A, Bergholm R, Yki-Järvinen H. Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects. Diabetes Care. 2008 Jan;31(1):165-9. Epub 2007 Oct 12.

Kotronen A, Juurinen L, Tiikkainen M, Vehkavaara S, Yki-Järvinen H. Increased Liver Fat, Impaired Insulin Clearance, and Hepatic and Adipose Tissue Insulin Resistance in Type 2 Diabetes. Gastroenterology. 2008 Mar 21. [Epub ahead of print]

Kotronen A, Seppälä-Lindroos A, Bergholm R, Yki-Järvinen H. Tissue specificity of insulin resistance in humans: fat in the liver rather than muscle is associated with features of the metabolic syndrome. Diabetologia. 2008 Jan;51(1):130-8. Epub 2007 Nov 16.

Kotronen A, Vehkavaara S, Seppälä-Lindroos A, Bergholm R, Yki-Järvinen H. Effect of liver fat on insulin clearance. Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1709-15. Epub 2007 Sep 25.

Kotronen A, Westerbacka J, Bergholm R, Pietilainen KH, Yki-Jarvinen H. Liver fat in the metabolic syndrome. J Clin Endocrinol Metab. 2007 Sep;92(9):3490-7.

Makkonen J, Westerbacka J, Kolak M, Sutinen J, Corner A, Hamsten A, Fisher RM, Yki-Jarvinen H. Increased expression of the macrophage markers and of 11beta-HSD-1 in subcutaneous adipose tissue, but not in cultured monocyte-derived macrophages, is associated with liver fat in human obesity. Int J Obes (Lond). 2007 Apr 24; [Epub ahead of print].

Matikainen N, Manttari S, Westerbacka J, Vehkavaara S, Lundbom N, Yki-Jarvinen H, Taskinen MR. Postprandial lipemia associates with liver fat content. J Clin Endocrinol Metab. 2007 Aug;92(8):3052-9. Epub 2007 May 8.

Slimani L, Oikonen V, Hallsten K, Savisto N, Knuuti J, Nuutila P, Iozzo P. Exercise restores skeletal muscle glucose delivery but not insulin-mediated glucose transport and phosphorylation in obese subjects. J Clin Endocrinol Metab. 2006 Jun 13; [Epub ahead of print].

Sysi-Aho M, Vehtari A, Velagapudi VR, Westerbacka J, Yetukuri L, Bergholm R, Taskinen MR, Yki-Jarvinen H, Oresic M. Exploring the lipoprotein composition using Bayesian regression on serum lipidomic profiles. Bioinformatics. 2007 Jul 1;23(13):i519-28.

Clinical and Genetic Epidemiological Studies

Berentzen T, Kring SI, Holst C, Zimmermann E, Jess T, Hansen T, Pedersen O, Toubro S, Astrup A, Sørensen TI. Lack of association of fatness-related FTO gene variants with energy expenditure or physical activity. J Clin Endocrinol Metab. 2008 Apr 29. [Epub ahead of print]

Boesgaard TW, Castella SI, Andersen G, Albrechtsen A, Sparsø T, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O. A -243A-->G polymorphism upstream of the gene encoding GAD65 associates with lower levels of body mass index and glycaemia in a population-based sample of 5857 middle-aged White subjects. Diabet Med. 2007 Jul;24(7):702-6. Epub 2007 Apr 24.

Jensen DP, Andreasen CH, Andersen MK, Hansen L, Eiberg H, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O. The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites. J Mol Med. 2007 May;85(5):445-9. Epub 2007 Jan 10.

Kring SI, Holst C, Zimmermann E, Jess T, Berentzen T, Toubro S, Hansen T, Astrup A, Pedersen O, Sørensen TI. FTO gene associated fatness in relation to body fat distribution and metabolic traits throughout a broad range of fatness. PLoS ONE. 2008 Aug 13;3(8):e2958.

Kring SII, Larsen LH, Holst C, Toubro S, Hansen T, Astrup A, Pedersen O, Sørensen TIAS. Genotype-Phenotype Associations in Obesity Dependent on Definition of the Obesity Phenotype. Obes Facts 2008;1:138-145 (DOI:10.1159/000137665).

Sparsø T, Hussain MS, Andersen G, Hainerova I, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O. Relationships between the functional PPARalpha Leu162Val polymorphism and obesity, type 2 diabetes, dyslipidaemia, and related quantitative traits in studies of 5799 middle-aged white people. Mol Genet Metab. 2007 Feb;90(2):205-9. Epub 2006 Nov 28.