Home | Summary | Pert Diagram | Participants | Project Management | Publications | Press | Jobs | Links | Members

Publications
Reviews
Original papers



search HEPADIP.org


Papers acknowledging HEPADIP


Theses

Abdelkarim M. Rôle du récepteur nucléaire Farnesoid X Receptor (FXR) dans la différenciation et la fonction adipocytaire. PhD thesis for Université Lille II 2010

Collins JM. Regulation of de novo lipogenesis and fatty acid desaturation in human adipocytes. DPhil thesis for the University of Oxford 2009

Jager J. Implication of MAP kinases ERK signaling pathways in adipose tissue inflammation and insulin resistance during obesity. PhD-thesis for Institut National de la Santé et de la Recherche Médicale (INSERM(N)) 2009

Kotronen A.. Liver fat in the metabolic syndrome and type 2 diabetes. PhD-thesis for the University of Helsinki, Faculty of Medicine, Institute of Clinical Medicine 2008

Lundbom J. Spectroscopy of tissue triglyceride composition: In vitro and in vivo studies, University of Helsinki, Dec 2010

Makkonen J. Adipose tissue inflammation, liver fat and insulin resistance in humans. PhD-thesis for the University of Helsinki, Faculty of Medicine, Institute of Clinical Medicine, Division of Diabetes Minerva Foundation Institute for Clinical Research 2010

Tencerova M. Molecular adaptations of human adipose tissue in response to dietary treatment of obesity. PhD-thesis for Charles University in Prague 2010

van Dijk TH. Computational Analysis of Carbohydrate Metabolism - Stable Isotope Techniques in Small Laboratory Animals. PhD-thesis for Groningen University 2010

Viljanen A: Effects of Weight Loss on Adipose Tissue, Liver and Heart Metabolism in Humans Annales Universitatis Turkuensis Ser D 861, 2009

Virtue S. A role for lipocalin prostaglandin D synthase in adipose tissue biology and the Metabolic Syndrome. PhD-thesis for University of Cambridge 2008

Pamphlet - Hepadip 2nd Annual Meeting 2006


Book Chapters

Sethi JK, Vidal-Puig AJ. Adipose Tissue Development, Structure and Function" In: Metabolic basis of obesity (Edn RS Ahima), Chapter 3, 2010

Usue Ariz, Jose Maria Mato, and Maria L. Martınez Chantar.
Nonalcoholic Steatohepatitis, Animal Models, and Biomarkers: What Is New? In: Bioinformatics Methods in Clinical Research. Humana Press 2010.

Yki-Järvinen H: Insulin resistance in type 2 diabetes. Textbook of Diabetes, Eds R. Holt, B. Goldstein, A. Flyvbjerg and C. Cocram. Fourth Edition. Blackwell Publishing, U.K.. Chapter 11, pp. 174-190, 2010

Yki-Järvinen H: Pathophysiology of type 2 diabetes. Oxford textbook of Endocrinology and Diabetes,  in press 2010

Yki-Järvinen H: Role of the fatty liver in the pathogenesis of type 2 diabetes. Publication of the FALK Workshop and Symposium 171 in Hannover, Germany. Edited by CP Day, D Vegani, F Negro, AM Diehl, ME Gershwin.  S. Karger AG, Basel, Switzerland, in press 2010


Reviews

Biology of Adipose Tissue

Andersson CX, Gustafson B, Hammarstedt A, Hedjazifar S, Smith U. Inflamed adipose tissue, insulin resistance and vascular injury. Diabetes Metab Res Rev. 2008 Aug 29. [Epub ahead of print]

Bézaire V, Langin D. Regulation of adipose tissue lipolysis revisited. Proc Nutr Soc. 2009 Nov;68(4):350-60. Epub 2009 Aug 24.

Chong Yew Tan and Antonio Vidal-Puig. The metabolic syndrome - where do we go from here? The Biochemist VOLUME 31 NO 3 June 2009

Frayn KN, Langin D, Karpe F. Fatty acid-induced mitochondrial uncoupling in adipocytes is not a promising target for treatment of insulin resistance unless adipocyte oxidative capacity is increased. Diabetologia. 2008 Mar;51(3):394-7. Epub 2007 Dec 21.

Gustafson B, Hammarstedt A, Andersson CX, Smith U. Inflamed Adipose Tissue: A Culprit Underlying the Metabolic Syndrome and Atherosclerosis. Arterioscler Thromb Vasc Biol. 2007 Sep 6; [Epub ahead of print].

Klimcakova E, Kovacikova M, Stich V, Langin D. Adipokines and dietary interventions in human obesity.Obes Rev. 2010 Jun;11(6):446-56. Epub 2010 Jan 6

Kolditz, C.I., and Langin, D. Adipose tissue lipolysis. Curr Opin Clin Nutr Metab Care 2010;13:377-381.

Lafontan M, Langin D. Lipolysis and lipid mobilization in human adipose tissue. Prog Lipid Res. 2009 Sep;48(5):275-97. Epub 2009 May 21.

Langin D. Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome. Pharmacol Res. 2006 Jun;53(6):482-91. Epub 2006 Mar 27.

Langin D. Control of fatty acid and glycerol release in adipose tissue lipolysis. C R Biol. 2006 Aug;329(8):598-607; discussion 653-5. Epub 2006 Apr 27. Review.

Langin D. Recruitment of brown fat and conversion of white into brown adipocytes: Strategies to fight the metabolic complications of obesity? Biochim Biophys Acta. 2010 Mar;1801(3):372-6.

Langin, D. Adipose tissue lipolysis revisited (again!): lactate involvement in insulin antilipolytic action. Cell Metab 2010;11:242-243.

Langin D, Arner P. Importance of TNFalpha and neutral lipases in human adipose tissue lipolysis. Trends Endocrinol Metab. 2006 Oct;17(8):314-320. Epub 2006 Aug 30.

Arner P, Langin D. The role of neutral lipases in human adipose tissue lipolysis. Curr Opin Lipidol. 2007 Jun;18(3):246-50. Review.

Sørensen TIA . Obesity Defined as Excess Storage of Inert Triglycerides – Do We Need a Paradigm Shift? Obes Facts 2011;4:91–94

Sedwick C. How cells cope with obesity. PLoS Biol 9(6)

Tan CY, Vidal-Puig A. Adipose tissue expandability: the metabolic problems of obesity may arise from the inability to become more obese. Biochem Soc Trans. 2008 Oct;36(Pt 5):935-40.

Tanti JF and Jager J. Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation. Curr Opin Pharmacol. 2009 Dec;9(6): 753-762.

Biology of Liver Tissue

Conde-Vancells J, Gonzalez E, Lu SC, Mato JM, Falcon-Perez JM. Overview of extracellular microvesicles in drug metabolism. Expert Opin Drug Metab Toxicol.2010 May;6(5):543-54.

Leclercq IA, Da Silva Morais A, Schroyen B, Van Hul N, Geerts A. Insulin Resistance in hepatocytes and sinusoidal liver cells: mechanisms and consequences. J Hepatol. 2007 Jul;47(1):142-56. Epub 2007 Apr 16.

Mato JM, Lu SC. Role of S-adenosyl-L-methionine in liver health and injury. Hepatology. 2007 May;45(5):1306-12. Review.

Mato JM, Martínez-Chantar ML, Lu SC. Methionine Metabolism and Liver Disease. Annu Rev Nutr. 2008 Aug 21;28:273-293.

Matthiesen R. Methods, algorithms and tools in computational proteomics: A practical point of view. Proteomics. 2007 Aug;7(16):2815-32.

Varela-Rey M, Embade N, Ariz U, Lu SC, Mato JM, Martínez-Chantar ML. Non-alcoholic steatohepatitis and animal models: understanding the human disease. Int J Biochem Cell Biol. 2009 May;41(5):969-76. Epub 2008 Nov 5.

Rodent Studies: The Adipose - Liver Axis

Cariou B, Staels B. FXR: a promising target for the metabolic syndrome? Trends Pharmacol Sci. 2007 May;28(5):236-43.

Cariou B, Staels B. The expanding role of the bile acid receptor FXR in the small intestine. J Hepatol. 2006 Jun;44(6):1213-5.

Caron S, Cariou B, Staels B. FXR: More than a bile acid receptor? Endocrinology. 2006 Sep;147(9):4022-4.

Christodoulides C, Lagathu C, Sethi JK, Vidal-Puig A. Adipogenesis and WNT signalling. Trends Endocrinol Metab. 2009 Jan;20(1):16-24. Epub 2008 Nov 13.


Kuipers F, Stroeve JHM, Caron S, Staels B. Bile acids, farnesoid X receptor, atherosclerosis and metabolic control. Curr Opin Lipidol. 2007 Jun;18(3):289-297.

Lage R, Diéguez C, Vidal-Puig A, López M. AMPK: a metabolic gauge regulating whole-body energy homeostasis. Trends Mol Med. 2008 Dec;14(12):539-49. Epub 2008 Nov 1.

Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B. Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev. 2009 Jan; 89(1):147-91. Review.

Medina-Gomez G, Gray S, Vidal-Puig A. Adipogenesis and lipotoxicity: role of peroxisome proliferator-activated receptor gamma (PPARgamma) and PPARgammacoactivator-1 (PGC1). Public Health Nutr. 2007 Oct;10(10A):1132-7.

Oresic M. Systems biology strategy to study lipotoxicity and the metabolic syndrome. Biochim Biophys Acta. 2010 Mar;1801(3):235-9.

Prawitt J, Caron S, Staels B. How to modulate FXR activity to treat the Metabolic Syndrome. Drug Discov Today Dis Mech. 2009 Dec;6(1-4):e55-e64

Sethi JK, Vidal-Puig AJ. Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res. 2007 Jun;48(6):1253-62.

Sethi JK, Vidal-Puig A. Wnt signalling and the control of cellular metabolism. Biochem J. 2010 Mar 15;427(1):1-17. Review.

Staels B, Kuipers F. Bile acid sequestrants and the treatment of type 2 diabetes mellitus. Drugs. 2007;67(10):1383-92.

Staels B, Maes M, Zambon A. Fibrates and future PPARalpha agonists in the treatment of cardiovascular disease. Nat Clin Pract Cardiovasc Med. 2008 Sep;5(9):542-53.

Virtue S, Vidal-Puig A. It's not how fat you are, it's what you do with it that counts. PLoS Biol. 2008 Sep 23;6(9):e237.

Virtue S, Vidal-Puig A Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspective.. Biochim Biophys Acta. 2010 Mar;1801(3):338-49. Epub 2010 Jan 6. Review.

Yetukuri L, Ekroos K, Vidal-Puig A, Oresic M. Informatics and computational strategies for the study of lipids. Mol Biosyst. 2008 Feb;4(2):121-7. Epub 2007 Dec 18. Review.

Human Studies: The Adipose - Liver Axis

Adiels M, Olofsson SO, Taskinen MR, Borén J. Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome. Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1225-36.

Frayn KN, Arner P, Yki-Jarvinen H. Fatty acid metabolism in adipose tissue, muscle and liver in health and disease. Essays Biochem. 2006;42:89-103. Review.

Kotronen A, Yki-Jarvinen H. Fatty Liver. A Novel Component of the Metabolic Syndrome. Arterioscler Thromb Vasc Biol. 2007 Aug 9.


So A, Thorens B. Uric acid transport and disease. J Clin Invest. 2010;120(6):1791-1799.

Tordjman J, Guerre-Millo M, Clément K. Adipose tissue inflammation and liver pathology in human obesity. Diabetes Metab. 2008 Dec;34(6 Pt 2):658-63.

Yki-Järvinen H.
Liver fat in the pathogensis of insulin resistance and type 2 diabetes. Dig Dis 28: 203-209, 2010.

Clinical and Genetic Epidemiological Studies

Berentzen T, Sørensen TIA. Effects of intended weight loss on morbidity and mortality: possible explanations of controversial results. Nutr Rev. 2006 Nov;64(11):502-7.

Jakobsen MU, Berentzen T, Sørensen TIA, Overvad K. Abdominal Obesity and Fatty Liver. Epidemiol Rev. 2007;29:77-87. Epub 2007 May 2.

Jakobsen MU, Overvad K. Observational epidemiological studies on intake of trans fatty acids and risk of ischaemic heart disease. In: Destaillats F, Sébédio JL, Dionisi F, Chardigny JM, eds. Trans fatty acids in human nutrition. Bridgwater, England: The Oily Press, 2009:255-306.

Sørensen TI. Challenges in the study of causation of obesity. Proceedings of the Nutrition Society 2009;68:43-54.

Sørensen TI, Virtue S, Vidal-Puig A. Obesity as a clinical and public health problem: is there a need for a new definition based on lipotoxicity effects? Biochim Biophys Acta. 2010 Mar;1801(3):400-4.

Tang J, Tan CY, Orešič M, Vidal-Puig A. Integrating post-genomic approaches as a strategy to advance our understanding of health and disease. Genome Med. 2009; 1:e35.

Verrijken A, Francque S, Van Gaal L. The metabolic syndrome and the liver. Acta Gastroenterol Belg. 2008 Jan-Mar;71(1):48-59. PMID: 18396752 [PubMed - in process].



Original Papers

Biology of Adipose Tissue

Andersson CX, Sopasakis VR, Wallerstedt E, Smith U. Insulin antagonizes IL-6 signaling and is anti-inflammatory in 3T3-L1 adipocytes. J Biol Chem. 2007 Mar 30;282(13):9430-5. Epub 2007 Jan 31.

Arner E, Rydén M, Arner P. Tumor necrosis factor alpha and regulation of adipose tissue. N Engl J Med. 2010 Mar 25;362(12):1151-3.

Aron-Wisnewsky J, Tordjman J, Poitou C, Darakhshan F, Hugol D, Basdevant A, Aissat A, Guerre-Millo M, Clément K. Human adipose tissue macrophages: m1 and m2 cell surface markers in subcutaneous and omental depots and after weight loss. J Clin Endocrinol Metab. 2009 Nov;94(11):4619-23. Epub 2009 Oct 16.

Aouadi M, Jager J, Laurent K, Gonzalez T, Cormont M, Binétruy B, Le Marchand-Brustel Y, Tanti JF, Bost F. p38MAP Kinase activity is required for human primary adipocyte differentiation. FEBS Lett. 2007 Dec 11;581(29):5591-6. Epub 2007 Nov 13.

Bajzová M, Kovaciková M, Vitková M, Klimcaková E, Polak J, Kovacová Z, Viguerie N, Vedral T, Mikulášek L, Sramková P, Srp A, Hejnová J, Langin D, Stich V. Retinol -binding protein 4 expression in visceral and subcutaneous fat in human obesity. Physiol Res. 2008;57(6):927-34.

Bertola A, Bonnafous S, Cormont M, Anty R, Tanti JF, Tran A, Le Marchand-Brustel Y, Gual P. Hepatocyte growth factor induces glucose uptake in 3T3-L1 adipocytes through a GAB1/ PI 3-kinase /GLUT4 pathway. J Biol Chem. 2007 Apr;282(14):10325-32. Epub 2007 Feb 6.

Bézaire V, Mairal A, Anesia R, Lefort C, Langin D. Chronic TNFalpha and cAMP pre-treatment of human adipocytes alter HSL, ATGL and perilipin to regulate basal and stimulated lipolysis. FEBS Lett. 2009 Sep 17;583(18):3045-9. Epub 2009 Aug 18.

Bezaire V, Mairal A, Ribet C, Lefort C, Girousse A, Jocken J, Laurencikiene J, Anesia R, Rodriguez AM, Ryden M, Stenson BM, Dani C, Ailhaud G, Arner P, Langin D. Contribution of Adipose Triglyceride Lipase and Hormone-sensitive Lipase to Lipolysis in hMADS Adipocytes. J Biol Chem. 2009 Jul 3;284(27):18282-91. Epub 2009 May 11.

Capel F, Klimcáková E, Viguerie N, Roussel B, Vítková M, Kováciková M, Polák J, Kovácová Z, Galitzky J, Maoret JJ, Hanácek J, Pers TH, Bouloumié A, Stich V, Langin D. Macrophages and Adipocytes in Human Obesity: Adipose Tissue Gene Expression and Insulin Sensitivity during Calorie Restriction and Weight Stabilization. Diabetes. 2009 Jul;58(7):1558-67. Epub 2009 Apr 28.

Chavey C, Lazennec G, Lagarrigue S, Clapé C, Iankova I, Teyssier J, Annicotte JS, Schmidt J, Mataki C, Yamamoto H, Sanches R, Guma A, Stich V, Vitkova M, Jardin-Watelet B, Renard E, Strieter R, Tuthill A, Hotamisligil GS, Vidal-Puig A, Zorzano A, Langin D, Fajas L. CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Cell Metab. 2009 Apr;9(4):339-49.

Dahlman I, Dicker A, Jiao H, Kere J, Blomqvist L, van Harmelen V, Hoffstedt J, Borch-Johnsen K, Jorgensen T, Hansen T, Pedersen O, Laakso M, Arner P. A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis. Am J Hum Genet. 2007 Jun;80(6):1115-24. Epub 2007 May 2.

Dahlman I, Forsgren M, Sjogren A, Nordstrom EA, Kaaman M, Naslund E, Attersand A, Arner P. Downregulation of Electron Transport Chain Genes in Visceral Adipose Tissue in Type 2 Diabetes Independent of Obesity and Possibly Involving Tumor Necrosis Factor-{alpha}. Diabetes. 2006 Jun;55(6):1792-9.

de Glisezinski I, Larrouy D, Bajzova M, Koppo K, Polak J, Berlan M, Bulow J, Langin D, Marques MA, Crampes F, Lafontan M, Stich V. Adrenaline but not noradrenaline is a determinant of exercise-induced lipid mobilization in human subcutaneous adipose tissue.J Physiol. 2009 Jul 1;587(Pt 13):3393-404. Epub 2009 May 5.

Dicker A, Aström G, Sjölin E, Hauner H, Arner P, van Harmelen V. The influence of preadipocyte differentiation capacity on lipolysis in human mature adipocytes. Horm Metab Res. 2007 Apr;39(4):282-7.

Dicker A, Aström G, Wåhlén K, Hoffstedt J, Näslund E, Wirén M, Rydén M, Arner P, van Harmelen V. Primary differences in lipolysis between human omental and subcutaneous adipose tissue observed using in vitro differentiated adipocytes. Horm Metab Res. 2009 May;41(5):350-5. Epub 2009 Feb 9.

Divoux A, Tordjman J, Lacasa D, Veyrie N, Hugol D, Aissat A, Basdevant A, Guerre-Millo M, Poitou C, Zucker JD, Bedossa P, Clément K. Fibrosis in human adipose tissue: composition, distribution and link with lipid metabolism and fat mass loss. Diabetes. 2010 Aug 16.

Flanagan JN, Linder K, Mejhert N, Dungner E, Wahlen K, Decaunes P, Rydén M, Björklund P, Arver S, Bhasin S, Bouloumie A, Arner P, Dahlman I. Role of follistatin in promoting adipogenesis in women.J Clin Endocrinol Metab. 2009 Aug;94(8):3003-9. Epub 2009 May 26.

Hainer V, Toplak H, Stich V. Fat or fit: what is more important? Diabetes Care. 2009 Nov;32 Suppl 2:S392-7.

Hannukainen JC, Kalliokoski KK, Borra RJ, Viljanen AP, Janatuinen T, Kujala UM, Kaprio J, Heinonen OJ, Viljanen T, Haaparanta M, Iozzo P, Parkkola R, Nuutila P. Higher Free Fatty Acid Uptake in Visceral Than in Abdominal Subcutaneous Fat Tissue in Men. Obesity (Silver Spring). 2009 Aug 20. [Epub ahead of print]

Henegar C, Tordjman J, Achard V, Lacasa D, Cremer I, Guerre-Millo M, Poitou C, Basdevant A, Stich V, Viguerie N, Langin D, Bedossa P, Zucker JD, Clement K. Adipose tissue transcriptomics signature highlights the pathological relevance of extracellular matrix in human obesity. Genome Biol. 2008 Jan 21;9(1):R14 [Epub ahead of print].

Hněvkovská Z, Dietrich J, Siklová-Vítková M, Kološtová K, Kováčiková M, Dušková M, Brož J, Vedral T, Stich V, Polák J.
Adiponectin inhibits spontaneous and catecholamine-induced lipolysis in human adipocytes of non-obese subjects through AMPK-dependent mechanisms. Physiol Res. 2010 Oct 15. [Epub ahead of print]

Jager J, Gremeaux T, Cormont M, Le Marchand-Brustel Y, Tanti JF. Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology. 2007 Jan;148(1):241-51. Epub 2006 Oct 12. PMID: 17038556 [PubMed - as supplied by publisher].

Jager J, Grémeaux T, Gonzalez T, Bonnafous S, Debard C, Laville M, Vidal H, Tran A, Gual P, Le Marchand-Brustel Y, Cormont M, Tanti JF. The Tpl2 kinase is up-regulated in adipose tissue in obesity and may mediate IL-1{beta} and TNF-{alpha} effects on ERK activation and lipolysis. Diabetes. 2010 Jan;59(1):61-70

Jager J, Corcelle V, Grémeaux T, Laurent K, Waget A, Pagès G, Binétruy B, Le Marchand-Brustel Y, Burcelin R, Bost F, Tanti JF. Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity. Diabetologia. 2010 Oct 15. [Epub ahead of print]

Jocken JW, Langin D, Smit E, Saris WH, Valle C, Hul GB, Holm C, Arner P, Blaak EE. Adipose triglyceride lipase and hormone-sensitive lipase protein expression is decreased in the obese insulin-resistant state. J Clin Endocrinol Metab. 2007 Jun;92(6):2292-9. Epub 2007 Mar 13.

Kaaman M, Sparks LM, van Harmelen V, Smith SR, Sjolin E, Dahlman I, Arner P. Strong association between mitochondrial DNA copy number and lipogenesis in human white adipose tissue. Diabetologia. 2007 Sep 19; [Epub ahead of print].

Kaddai V, Gonzalez T, Keslair F, Grémeaux T, Bonnafous S, Gugenheim J, Tran A, Gual P, Le Marchand-Brustel Y, Cormont M. Rab4b is a small GTPase involved in the control of the glucose transporter GLUT4 localization in adipocyte. PLoS One 2009 4(4):e5257.

Kaddai V, Jager J, Gonzalez T, Najem-Lendom R, Bonnafous S, Tran A, Le Marchand-Brustel Y, Gual P, Tanti JF, Cormont M. Involvement of TNF-alpha in abnormal adipocyte and muscle sortilin expression in obese mice and humans. Diabetologia 2009 May;52(5):932-40.

Klimcakova E, Moro C, Mazzucotelli A, Lolmède K, Viguerie N, Galitzky J, Stich V, Langin D. Profiling of adipokines secreted from human subcutaneous adipose tissue in response to PPAR agonists. Biochem. Biophys. Res. Commun. 2007 Jul 6;358(3):897-902.

Klimcakova, E., Roussel, B., Marquez-Quinones, A., Kovacova, Z., Kovacikova, M., Combes, M., Siklova-Vitkova, M., Hejnova, J., Sramkova, P., Bouloumie, A., et al. Worsening of Obesity and Metabolic Status Yields Similar Molecular Adaptations in Human Subcutaneous and Visceral Adipose Tissue: Decreased Metabolism and Increased Immune Response. J Clin Endocrinol Metab 2010 Nov 3. [Epub ahead of print]

Koppo K, Larrouy D, Marques MA, Berlan M, Bajzova M, Polak J, Van de Voorde J, Bülow J, Lafontan M, Crampes F, Langin D, Stich V, de Glisezinski I. Lipid mobilization in subcutaneous adipose tissue during exercise in lean and obese humans. Roles of insulin and natriuretic peptides. Am J Physiol Endocrinol Metab. 2010 Aug;299(2):E258-65. Epub 2010 May 18

Kováciková M, Sengenes C, Kovácová Z, Siklová-Vítková M, Klimcáková E, Polák J, Rossmeislová L, Bajzová M, Hejnová J, Hnevkovská Z, Bouloumié A, Langin D, Stich V. Dietary intervention-induced weight loss decreases macrophage content in adipose tissue of obese women. Int J Obes (Lond). 2010 Jun 8.

Kovacikova M, Vitkova M, Klimcakova E, Polak J, Hejnova J, Bajzova M, Kovacova Z, Viguerie N, Langin D, Stich V. Visfatin expression in subcutaneous adipose tissue of pre-menopausal women: relation to hormones and weight reduction. Eur J Clin Invest. 2008 Jul;38(7):516-22.

Kovacova Z, Vitkova M, Kovacikova M, Klimcakova E, Bajzova M, Hnevkovska Z, Rossmeislova L, Stich V, Langin D, Polak J. Secretion of adiponectin multimeric complexes from adipose tissue explants is not modified by very low calorie diet. Eur J Endocrinol. 2009 Apr;160(4):585-92. Epub 2009 Jan 20.

Langin D, Dicker A, Tavernier G, Hoffstedt J, Mairal A, Ryden M, Arner E, Sicard A, Jenkins CM, Viguerie N, van Harmelen V, Gross RW, Holm C, Arner P. Adipocyte lipases and defect of lipolysis in human obesity. Diabetes. 2005 Nov;54(11):3190-7.

Laurencikiene J, Stenson BM, Arvidsson Nordström E, Agustsson T, Langin D, Isaksson B, Permert J, Rydén M, Arner P. Evidence for an important role of CIDEA in human cancer cachexia. Cancer Res. 2008 Nov 15;68(22):9247-54.

Laurencikiene J, van Harmelen V, Arvidsson Nordstrom E, Dicker A, Blomqvist L, Naslund E, Langin D, Arner P, Ryden M. NF-kappaB is important for TNF-alpha-induced lipolysis in human adipocytes. J Lipid Res. 2007 May;48(5):1069-77.

Lång P, van Harmelen V, Rydén M, Kaaman M, Parini P, Carneheim C, Cassady AI, Hume DA, Andersson G, Arner P. Monomeric tartrate resistant acid phosphatase induces insulin sensitive obesity. PLoS ONE. 2008 Mar 5;3(3):e1713.

Mairal A, Langin D, Arner P, Hoffstedt J. Human adipose triglyceride lipase (PNPLA2) is not regulated by obesity and exhibits low in vitro triglyceride hydrolase activity. Diabetologia. 2006 Jul;49(7):1629-36. Epub 2006 May 10.

Mazzucotelli A, Ribet C, Castan-Laurell I, Daviaud D, Guigné C, Langin D, Valet P. The transcriptional co-activator PGC-1alpha up regulates apelin in human and mouse adipocytes. Regul Pept. 2008 Oct 9;150(1-3):33-7. Epub 2008 Apr 13.

Mazzucotelli A, Viguerie N, Tiraby C, Annicotte JS, Mairal A, Klimcakova E, Lepin E, Delmar P, Dejean S, Tavernier G, Lefort C, Hidalgo J, Pineau T, Fajas L, Clement K, Langin D. The transcriptional coactivator peroxisome proliferator activated receptor (PPAR)gamma coactivator-1 alpha and the nuclear receptor PPAR alpha control the expression of glycerol kinase and metabolism genes independently of PPAR gamma activation in human white adipocytes. Diabetes. 2007 Oct;56(10):2467-75. Epub 2007 Jul 23.

Mejhert N, Galitzky J, Pettersson AT, Bambace C, Blomqvist L, Bouloumié A, Frayn KN, Dahlman I, Arner P, Rydén M. Mapping of the Fibroblast Growth Factors in Human White Adipose Tissue. J Clin Endocrinol Metab. 2010 May;95(5):2451,2457.

Moro C, Klimcakova E, Lolmede K, Berlan M, Lafontan M, Stich V, Bouloumie A, Galitzky J, Arner P, Langin D. Atrial natriuretic peptide inhibits the production of adipokines and cytokines linked to inflammation and insulin resistance in human subcutaneous adipose tissue. Diabetologia. 2007 May;50(5):1038-47. Epub 2007 Feb 23.

Pettersson AT, Laurencikiene J, Mejhert N, Näslund E, Bouloumié A, Dahlman I, Arner P, Rydén M. A possible inflammatory role of twist1 in human white adipocytes. Diabetes 2010: 59(3).564-71

Pettersson T A, Mejhert N, Jernås M, Carlsson MS, Dahlman I, Laurencikiene J, Arner P. Rydén M. Twist1 in human white adipose tissue and obesity. J Clin endocrine Metab. 2010; Okt 13.

Prawitt J, Abdelkarim M, Stroeve JH, Popescu I, Duez H, Velagapudi VR, Dumont J, Bouchaert E, van Dijk TH, Lucas A, Dorchies E, Daoudi M, Lestavel S, Gonzalez FJ, Oresic M, Cariou B, Kuipers F, Caron S, Staels B. Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity. Diabetes. 2011 May 18.

Polak J, Kovacova Z, Holst C, Verdich C, Astrup A, Blaak E, Patel K, Oppert JM, Langin D, Martinez JA, Sørensen TI, Stich V. Total adiponectin and adiponectin multimeric complexes in relation to weight loss-induced improvements in insulin sensitivity in obese women: the NUGENOB study.Eur J Endocrinol. 2008 Apr;158(4):533-41.

Polak J, Moro C, Bessiere D, Hejnova J, Marques MA, Bajzova M, Lafontan M, Crampes F, Berlan M, Stich V. Acute exposure to long-chain fatty acids impairs {alpha}2-adrenergic receptor-mediated antilipolysis in human adipose tissue. J Lipid Res. 2007 Oct;48(10):2236-46. Epub 2007 Jul 11.

Polak J, Moro C, Klimcakova E, Kovacikova M, Bajzova M, Vitkova M, Kovacova Z, Sotornik R, Berlan M, Viguerie N, Langin D, Stich V. The atrial natriuretic peptide- and catecholamine-induced lipolysis and expression of related genes in adipose tissue in hypothyroid and hyperthyroid patients. Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E246-51. Epub 2007 Mar 27.

Regazzetti C, Bost F, Le Marchand-Brustel Y, Tanti JF, Giorgetti-Peraldi S. Insulin induces REDD1 expression through Hypoxia Inducible Factor-1 (HIF-1) activation in adipocytes. J Biol Chem. 2010 Feb 19;285(8):5157-64. Epub 2009 Dec 8.

Regazzetti C, Peraldi P, Grémeaux T, Najem-Lendom R, Ben-Sahra I, Cormont M, Bost F, Le Marchand-Brustel Y, Tanti JF, Giorgetti-Peraldi S. Hypoxia Decreases Insulin Signaling Pathways in Adipocytes. Diabetes 2009 58: 95-103.

Ribet C, Montastier E, Valle C, Bezaire V, Mazzucotelli A, Mairal A, Viguerie N, Langin D. Peroxisome Proliferator-Activated Receptor-{alpha} Control of Lipid and Glucose Metabolism in Human White Adipocytes. Endocrinology. 2010 Jan;151(1):123-33.

Ryden M, Jocken J, van Harmelen V, Dicker A, Hoffstedt J, Wiren M, Blomqvist L, Mairal A, Langin D, Blaak EE, Arner P. Comparative Studies of the Role of Hormone Sensitive Lipase and Adipose Triglyceride Lipase in Human Fat Cell Lipolysis. Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1847-55. Epub 2007 Feb 27.

Seale P, Kajimura S, Yang W, Chin S, Rohas LM, Uldry M, Tavernier G, Langin D, Spiegelman BM. Transcriptional Control of Brown Fat Determination by PRDM16. Cell Metab. 2007 Jul;6(1):38-54. PMID: 17618855 [PubMed - in process].

Sell H, Divoux A, Poitou C, Basdevant A, Bouillot JL, Bedossa P, Tordjman J, Eckel J, Clément K.Chemerin correlates with markers for fatty liver in morbidly obese patients and strongly decreases after weight loss induced by bariatric surgery. J Clin Endocrinol Metab. 2010 Jun; 95(6):2892-6. Epub 2010 Apr 7.

Skogsberg J, Dicker A, Rydén M, Aström G, Nilsson R, Bhuiyan H, Vitols S, Mairal A, Langin D, Alberts P, Walum E, Tegnér J, Hamsten A, Arner P, Björkegren J. ApoB100-LDL acts as a metabolic signal from liver to peripheral fat causing inhibition of lipolysis in adipocytes. PLoS One. 2008;3(11):e3771. Epub 2008 Nov 20.

Stenson BM, Rydén M, Steffensen KR, Wåhlén K, Pettersson AT, Jocken JW, Arner P, Laurencikiene J. Activation of liver X receptor regulates substrate oxidation in white adipocytes.Endocrinology. 2009 Sep;150(9):4104-13. Epub 2009 Jun 25.

van Harmelen V, Eriksson A, Aström G, Wåhlén K, Näslund E, Karpe F, Frayn K, Olsson T, Andersson J, Rydén M, Arner P. Vascular peptide endothelin-1 links fat accumulation with alterations of visceral adipocyte lipolysis Diabetes. 2008 Feb;57(2):378-86. Epub 2007 Nov 19.

van Harmelen V, Dicker A, Sjölin E, Blomqvist L, Wirén M, Hoffstedt J, Rydén M, Arner P. Effects of pain controlling neuropeptides on human fat cell lipolysis. Int J Obes 34, 1333-1340, 2010.

Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerbäck S, Nuutila P. Functional brown adipose tissue in healthy adults. N Engl J Med. 2009 Apr 9;360(15):1518-25. Erratum in: N Engl J Med. 2009 Sep 10;361(11):1123.

Vitkova M, Klimcakova E, Kovacikova M, Valle C, Moro C, Polak J, Hanacek J, Capel F, Viguerie N, Richterova B, Bajzova M, Hejnova J, Stich V, Langin D. Plasma levels and adipose tissue messenger ribonucleic acid expression of retinol-binding protein 4 are reduced during calorie restriction in obese subjects but are not related to diet-induced changes in insulin sensitivity. J Clin Endocrinol Metab. 2007 Jun;92(6):2330-5. Epub 2007 Apr 3.

Wallerstedt E, Smith U, Andersson CX. Protein kinase C-delta is involved in the inflammatory effect of IL-6 in mouse adipose cells. Diabetologia. 2010 Feb 12. [Epub ahead of print]

Biology of Liver Tissue

Anty R, Dahman M, Iannelli A, Gual P, Staccini-Myx A, Amor IB, Luciani N, Saint-Paul MC, Huet PM, Sadoul JL, Srai SK, Unwin R, Gugenheim J, Le Marchand-Brustel Y, Tran A, Bekri S. Bariatric surgery can correct iron depletion in morbidly obese women: a link with chronic inflammation. Obes Surg. 2008 Jun;18(6):709-14. Epub 2008 Mar 11.

Anty R, Iannelli A, Patouraux S, Bonnafous S, Lavallard V, Senni-Buratti M, Ben Amor I, Staccini-Myx A, Saint-Paul MC, Berthier F, Huet PM, Le Marchand-Brustel Y, Gugenheim J, Gual P, Tran A. A new composite model including metabolic syndrome, alanine aminotransferase and cytokeratin-18 for the diagnosis of non-alcoholic steatohepatitis in morbidly obese patients.

Barr J, Alonso C, Vázquez-Chantada M, Perez-Cormenzana M, Mayo R, Galán A, Caballeria J, Martin-Duce A, Tran A, Wagner C, Luka Z, Lu SC, Castro A, Le Marchand-Brustel Y, Martinez-Chantar ML, Veyrie N, Clément K, Tordjman J, Gual P, Mato JM.
Liquid Chromatography-Mass Spectrometry (LC/MS)-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of non-alcoholic fatty liver disease. J Proteome Res. 2010 Jul 15. [Epub ahead of print]

Bertola A, Deveaux V, Bonnafous S, Rousseau D, Anty R, Wakkach A, Dahman M, Tordjman J, Clément K, McQuaid SE, Frayn KN, Huet PM, Gugenheim J, Lotersztajn S, Le Marchand-Brustel Y, Tran A, Gual P. Elevated Expression of Osteopontin May Be Related to Adipose Tissue Macrophage Accumulation and Liver Steatosis in Morbid Obesity. Diabetes. 2009 Jan;58(1):125-33.

Bertola A, Bonnafous S, Anty R, Patouraux S, Saint-Paul C, Iannelli A, Gugenheim J, Barr J, Mato JM, Le Marchand-Brustel Y, Tran A, Gual P. Hepadip expression patterns in inflammatory and immune response genes associated with obesity and NASH in morbidly obese patients. PLoS One 2010 Oct 22;5(10):e13577.

Calvanese V, Lara E, Suárez-Álvarez B, Dawud RA, Vázquez-Chantada M, Martínez-Chantar ML, Embade N, López-Nieva P, Horrillo A, Hmadcha A, Soria B, Piazzolla D, Herranz D, Serrano M, Mato JM, Andrews PW, López-Larrea C, Esteller, Fraga MF. Sirtuin 1 regulation of developmental genes during differentiation of stem cells. Proc Natl Acad Sci U S A 2010 Aug 3;107(31):13736-41. Epub 2010 Jul 14.

Chen H, Xia M, Lin M, Yang H, Kuhlenkamp J, Li T, Sodir NM, Chen YH, Josef-Lenz H, Laird PW, Clarke S, Mato JM, Lu SC. Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterology. 2007 Jul;133(1):207-18. Epub 2007 Apr 11. Erratum in: Gastroenterology. 2007 Nov;133(5):1747.

Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM. Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes. J Proteome Res. 2008 Dec;7(12):5157-66.

Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez JM. Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.Proteomics Clin Appl. 2010 Feb 3;4(4):416-425.

Ding W, Mouzaki M, You H, Laird J, Mato JM, Lu SC, Rountree CB. CD 133 + Liver Cancer Stem Cells from Methionine Adenosyl Transferase 1A Deficient Mice Demonstrate Resistance to TGF-β induced apoptosis. Hepatology 2009 April;49:1277-86.

Dushay J, Chui PC, Gopalakrishnan GS, Varela-Rey M, Crawley M, Fisher FM, Badman MK, Martinez-Chantar ML, Maratos-Flier E. Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease. Gastroenterology 2010 Aug;139(2):456-63. Epub 2010 May 5.

Fernández-Millán P, Kortazar D, Lucas M, Martínez-Chantar ML, Astigarraga E, Fernández JA, Sabas O, Albert A, Mato JM, Martínez-Cruz LA. Crystallization and preliminary crystallographic analysis of merohedrally twinned crystals of MJ0729, a CBS-domain protein from Methanococcus jannaschii. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jul 1;64(Pt 7):605-9. Epub 2008 Jun 7.PMID: 18607087 [PubMed - in process]

Gómez García I, Kortázar D, Oyenarte I, Mato JM, Martínez-Chantar ML, Martínez-Cruz LA. Purification, crystallization and preliminary crystallographic analysis of protein MJ1225 from Methanocaldococcus jannaschii, a putative archaeal homologue of gamma-AMPK. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Aug;65(Pt 8):813-7. Epub 2009 Jul.

Guimarães EL, Empsen C, Geerts A, van Grunsven LA. Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells. J Hepatol. 2010 Mar;52(3):389-97.

Iannelli A, Anty R, Piche T, Dahman M, Gual P, Tran A, Gugenheim J. Impact of laparoscopic Roux-en-Y gastric bypass on metabolic syndrome, inflammation, and insulin resistance in super versus morbidly obese women. Obes Surg. 2009;19(5):577-82.

Ko KS, Tomasi ML, Iglesias-Ara A, French BA, French SW, Ramani K, Lozano JJ, Oh P, He L, Stiles BL, Li TWH, Yang H, Martınez-Chantar ML, Mato JM, Lu SC. Liver-Specific Deletion of Prohibitin 1 Results in
Spontaneous Liver Injury, Fibrosis, and Hepatocellular Carcinoma in Mice. Hepatology 2010 Aug 20. [Epub ahead of print]

Kudomi N, Slimani L, Järvisalo MJ, Kiss J, Lautamäki R, Naum GA, Savunen T, Knuuti J, Iida H, Nuutila P, Iozzo P. Non-invasive estimation of hepatic blood perfusion from H(2) (15)O PET images using tissue-derived arterial and portal input functions. Eur J Nucl Med Mol Imaging. 2008 Oct;35(10):1899-911. Epub 2008 May 6. PMID: 18458902 [PubMed - in process]

Lara E, Mai A, Calvanese V, Altucci L, Lopez-Nieva P, Martinez-Chantar ML, Varela-Rey M, Rotili D, Nebbioso A, Ropero S, Montoya G, Oyarzabal J, Velasco S, Serrano M, Witt M, Villar-Garea A, Imhof A, Mato JM, Esteller M, Fraga MF. Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene. 2009 Feb 12;28(6):781-91.

Li TW, Zhang Q, Oh P, Xia M, Chen H, Bemanian S, Lastra N, Circ M, Moyer MP, Mato JM, Aw TY, Lu SC. S-Adenosylmethionine and methylthioadenosine inhibit cellular FLICE inhibitory protein expression and induce apoptosis in colon cancer cells.Mol Pharmacol. 2009 Jul;76(1):192-200. Epub 2009 Apr 16.

Li J, Ramani K, Sun Z, Zee C, Grant EG, Yang H, Xia M, Oh P, Ko K, Mato JM, Lu SC.
Forced Expression of Methionine Adenosyltransferase 1A in Human Hepatoma Cells Suppresses in Vivo Tumorigenicity in Mice. Am J Pathil 2010 May;176(5):2456-66. Epub 2010 Apr 2.

Lu SC, Ramani K, Ou X, Lin M, Yu V, Ko K, Park R, Bottiglieri T, Tsukamoto H, Kanel G, French SW, Mato JM, Moats R, Grant E. S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model.Hepatology. 2009 Aug;50(2):462-71.

Lucas M, Kortazar D, Astigarraga E, Fernández JA, Mato JM, Martínez-Chantar ML, Martínez-Cruz LA. Purification, crystallization and preliminary X-ray diffraction analysis of the CBS-domain pair from the Methanococcus jannaschii protein MJ0100. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Oct 1;64(Pt 10):936-41. Epub 2008 Sep 30.PMID: 18931440 [PubMed - in process]

Lucas M, Encinar JA, Arribas EA, Oyenarte I, García IG, Kortazar D, Fernández  JA, Mato JM, Martínez-Chantar ML, Martínez-Cruz LA. Binding of S-Methyl-5'-Thioadenosine and S Adenosyl-l-Methionine to Protein MJ0100 Triggers  an Open-to-Closed Conformational Change in Its CBS Motif Pair. J Mol Biol. 2009 Dec 21.

Martínez-Chantar ML, Vázquez-Chantada M, Ariz U, Martínez N, Varela M, Luka Z, Capdevila A, Rodríguez J, Aransay AM, Matthiesen R, Yang H, Calvisi DF, Esteller M, Fraga M, Lu SC, Wagner C, Mato JM. Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. Hepatology. 2008 Apr;47(4):1191-9.

Martínez-Cruz LA, Encinar JA, Kortazar D, Prieto J, Gómez J, Fernández-Millán P, Lucas M, Arribas EA, Fernández JA, Martínez-Chantar ML, Mato JM, Neira JL. The CBS domain protein MJ0729 of Methanocaldococcus jannaschii is a thermostable protein with a pH-dependent self-oligomerization.Biochemistry. 2009 Mar 31;48(12):2760-76.

Martínez-López N, Varela-Rey M, Ariz U, Embade N, Vazquez-Chantada M, Fernandez-Ramos D, Gomez-Santos L, Lu SC, Mato JM, Martinez-Chantar ML. S-adenosylmethionine and proliferation: new pathways, new targets. Biochem Soc Trans. 2008 Oct;36(Pt 5):848-52. PMID: 18793149 [PubMed - in process]

Martınez-Lopez N, Varela-Rey M, Fernandez-Ramos D, Woodhoo A, Vazquez-Chantada M, Embade N, Espinosa-Hevia L, Bustamante FJ. Parada LA, Rodriguez MS, Lu SC, Mato JM, Martınez-Chantar ML. Activation of LKB1-Akt Pathway Independent of Phosphoinositide 3-Kinase Plays a Critical Role in the Proliferation of Hepatocellular Carcinoma from Nonalcoholic Steatohepatitis. Hepatology 2010 Nov;52(5):1621-31.

Omaetxebarria MJ, Elortza F, Rodríguez-Suárez E, Aloria K, Arizmendi JM, Jensen ON, Matthiesen R. Computational approach for identification and characterization of GPI-anchored peptides in proteomics experiments. Proteomics. 2007 Jun;7(12):1951-60.

Ou X, Yang H, Ramani K, Ara AI, Chen H, Mato JM, Lu SC. Inhibition of human betaine-homocysteine methyltransferase expression by S-adenosylmethionine and methylthioadenosine. Biochem J. 2007 Jan 1;401(1):87-96.

Ramani K, Yang H, Xia M, Ara AI, Mato JM, Lu SC. Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta.Hepatology. 2008 Feb;47(2):521-31.

Ramani K, Yang H, Kuhlenkamp J, Tomasi L, Tsukamoto H, Mato JM, Lu SC
.Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation.Hepatology. 2010 Mar;51(3):986-95.

Rodríguez JL, Boukaba A, Sandoval J, Georgieva EI, Latasa MU, García-Trevijano ER, Serviddio G, Nakamura T, Avila MA, Sastre J, Torres L, Mato JM, López-Rodas G. Transcription of the MAT2A gene, coding for methionine adenosyltransferase, is up-regulated by E2F and Sp1 at a chromatin level during proliferation of liver cells.Int J Biochem Cell Biol. 2007;39(4):842-50. Epub 2007 Jan 20.

Rountree CB, Senadheera S, Mato JM, Crooks GM, Lu SC. Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice. Hepatology. 2008 Apr;47(4):1288-97.

Rubio A, Guruceaga E, Vázquez-Chantada M, Sandoval J, Martínez-Cruz LA, Segura V, Sevilla JL, Podhorski A, Corrales FJ, Torres L, Rodríguez M, Aillet F, Ariz U, Arrieta FM, Caballería J, Martín-Duce A, Lu SC, Martínez-Chantar ML, Mato JM. Identification of a gene-pathway associated with non-alcoholic steatohepatitis. J Hepatol. 2007 Apr;46(4):708-18. Epub 2006 Nov 30.

Slimani L, Kudomi N, Oikonen V, Jarvisalo M, Kiss J, Naum A, Borra R, Viljanen A, Sipila H, Ferrannini E, Savunen T, Nuutila P, Iozzo P. Quantification of liver perfusion with [(15)O]H(2)O-PET and its relationship with glucose metabolism and substrate levels. J Hepatol. 2008 Jun;48(6):974-82. Epub 2008 Mar 4. PMID: 18384905 [PubMed - indexed for MEDLINE]

Tomasi ML, Iglesias-Ara A, Yang H, Ramani K, Feo F, Pascale MR, Martínez-Chantar ML, Mato JM, Lu SC. S-adenosylmethionine regulates apurinic/apyrimidinic endonuclease 1 stability: implication in hepatocarcinogenesis.Gastroenterology. 2009 Mar;136(3):1025-36. Epub 2008 Sep 25.

Tomasi ML, Ramani K, Lopitz-Otsoa F, Rodrıguez MS, Li TWH, Ko K, Yang H, Bardag-Gorce F, Iglesias-Ara A, Feo F, Pascale MR, Mato JM, Lu SC. S-Adenosylmethionine Regulates Dual-Specificity Mitogen-Activated Protein Kinase Phosphatase Expression in Mouse and Human Hepatocytes. Hepatology 2010 Jun;51(6):2152-61.

Varela-Rey M, Fernández-Ramos D, Martínez-López N, Embade N, Gómez-Santos L, Beraza N, Vázquez-Chantada M, Rodríguez J, Luka Z, Wagner C, Lu SC, Martínez-Chantar ML, Mato JM. Impaired liver regeneration in mice lacking glycine N-methyltransferase. Hepatology. 2009 Apr 17. [Epub ahead of print]

Varela-Rey M, Martínez-López N, Fernández-Ramos D, Embade N, Calvisi DF, Woodhoo A, Rodríguez J, Fraga MF, Julve J, Rodríguez-Millán E, Frades I, Torres L, Luka Z, Wagner C, Esteller M, Lu SC, Martínez-Chantar ML,
Mato JM.
Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide. Hepatology 2010 Jul;52(1):105-14.

Vázquez-Chantada M, Ariz U, Varela-Rey M, Embade N, Martínez-Lopez N, Fernández-Ramos D, Gómez-Santos L, Lamas S, Lu SC, Martínez-Chantar ML, Mato JM. Evidence for LKB1/AMP-activated protein kinase/ endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxide in hepatocyte proliferation.Hepatology. 2009 Feb;49(2):608-17.

Vázquez-Chantada M, Fernández-Ramos D, Embade N, Martinez-Lopez N, Varela-Rey M, Woodhoo A, Luka Z, Wagner C, Anglin PP, Finnell RH, Caballeria J, Laird-Offringa A, Gorospe M, Lu SC, Mato JM, Mertinez-Chantar ML. HuR/Methyl-HuR and AUF1 Regulate the MAT Expressed During Liver Proliferation, Differentiation, and Carcinogenesis. Gastroenterology 2010 May;138(5):1943-53. Epub 2010 Jan 25.

Xia M, Chen Y, Wang LC, Zandi E, Yang H, BemanianS, Martínez-Chantar ML, Mato JM, Lu SC.
Novel Function and Intracellular Localization of Methionine Adenosyltransferase 2 Splicing Variants. J Biol Chem 2010 Jun 25;285(26):20015-21. Epub 2010 Apr 26.

Yang H, Magilnick N, Noureddin M, Mato JM, Lu SC. Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells. J Cell Physiol. 2007 Mar;210(3):766-73.

Yuan JM, Lu SC, Van Den Berg D, Govindarajan S, Zhang ZQ, Mato JM, Yu MC. Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma. Hepatology. 2007 Sep;46(3):749-58.

Rodent Studies: The Adipose - Liver Axis

Abdelkarim M, Caron S, Duhem C, Prawitt J, Dumont J, Lucas A, Bouchaert E, Briand O, Brozek J, Kuipers F, Fievet C, Cariou B, Staels B. The farnesoid X receptor regulates adipocyte differentiation and function by promoting peroxisome proliferator-activated receptor-gamma and interfering with the WNT/{beta} catenin pathways. J Biol Chem. 2010 Sep 20.

Cariou B, Bouchaert E, Abdelkarim M, Dumont J, Caron S, Fruchart JC, Burcelin R, Kuipers F, Staels B. FXR-deficiency confers increased susceptibility to torpor. FEBS Lett. 2007 Nov 13;581(27):5191-8. Epub 2007 Oct 12.

Cariou B, van Harmelen K, Duran-Sandoval D, van Dijk TH, Grefhorst A, Abdelkarim M, Caron S, Torpier G, Fruchart JC, Gonzalez FJ, Kuipers F, Staels B. The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice. J Biol Chem. 2006 Apr 21;281(16):11039-49. Epub 2006 Jan 30.

Duran-Sandoval D, Cariou B, Percevault F, Hennuyer N, Grefhorst A, van Dijk TH, Gonzalez FJ, Fruchart JC, Kuipers F, Staels B. The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition. J Biol Chem. 2005 Aug 19;280(33):29971-9. Epub 2005 May 16.

Gineste R, Sirvent A, Paumelle R, Helleboid S, Aquilina A, Darteil R, Hum DW, Fruchart JC, Staels B. Phosphorylation of farnesoid X receptor by protein kinase C promotes its transcriptional activity. Mol Endocrinol. 2008 Nov;22(11):2433-47.

Gray SL, Dalla Nora E, Backlund EC, Manieri M, Virtue S, Noland RC, O'Rahilly S, Cortright RN, Cinti S, Cannon B, Vidal-Puig A. Decreased brown adipocyte recruitment and thermogenic capacity in mice with impaired peroxisome proliferator-activated receptor (P465L PPARgamma) function.Endocrinology. 2006 Dec;147(12):5708-14.

Gray SL, Dalla Nora E, Grosse J, Manieri M, Stoeger T, Medina-Gomez G, Burling K, Wattler S, Russ A, Yeo G, Chatterjee V, O’Rahilly S, Voshol P, Cinti S, Vidal-Puig A. Leptin deficiency unmasks the deleterious effects of impaired PPARγ function (P465L PPARγ) in mice. Diabetes. 2006 Oct;55(10):2669-2677.

Hall D, Poussin C, Velagapudi VR, Empsen C, Joffraud M, Beckmann J, Geerts AE, Ravussin Y, Ibberson M, Oresic M, Thorens B. Peroxisomal and microsomal lipid pathways associated with resistance to hepatic steatosis and reduced pro-inflammatory state. J Biol Chem. 2010 Jul 6. [Epub ahead of print].

Lagathu C, Christodoulides C, Virtue S, Cawthorn WP, Franzin C, Kimber WA, Nora ED, Campbell M, Medina-Gomez G, Cheyette BN, Vidal-Puig AJ, Sethi JK. Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling network. Diabetes. 2009 Mar;58(3):609-19. Epub Dec 2008.

Lagathu C, Christodoulides C, Tan CY, Virtue S, Laudes M, Campbell M, Ishikawa K, Ortega F, Tinahones FJ, Fernández-Real JM, Orešič M, Sethi JK, Vidal-Puig A. Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity. Int J Obes (Lond). 2010 Jun 1.

Lage R, Vázquez MJ, Varela L, Saha AK, Vidal-Puig A, Nogueiras R, Diéguez C, López M. Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender. FASEB J. 2010 Aug;24(8):2670-9. Epub 2010 Mar 24.

Lalloyer F, Vandewalle B, Percevault F, Torpier G, Kerr-Conte J, Oosterveer M, Paumelle R, Fruchart J-C, Kuipers F, Pattou F, Fiévet C, Staels B. Peroxisome Proliferator–Activated Receptor Improves Pancreatic Adaptation to Insulin Resistance in Obese Mice and Reduces Lipotoxicity in Human Islets. Diabetes. 2006 Jun;55:1605-1613.

López M, Lage R, Saha AK, Pérez-Tilve D, Vázquez MJ, Varela L, Sangiao-Alvarellos S, Tovar S, Raghay K, Rodríguez-Cuenca S, Deoliveira RM, Castañeda T, Datta R, Dong JZ, Culler M, Sleeman MW, Alvarez CV, Gallego R, Lelliott CJ, Carling D, Tschöp MH, Diéguez C, Vidal-Puig A. Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab. 2008 May;7(5):389-99.

López M, Varela L, Vázquez MJ, Rodríguez-Cuenca S, González CR, Velagapudi VR, Morgan DA, Schoenmakers E, Agassandian K, Lage R, Martínez de Morentin PB, Tovar S, Nogueiras R, Carling D, Lelliott C, Gallego R, Oresic M, Chatterjee K, Saha AK, Rahmouni K, Diéguez C, Vidal-Puig A. Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med. 2010 Sep;16(9):1001-8.

Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GSH, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A. PPAR gamma 2 Prevents Lipotoxicity by Controlling Adipose Tissue Expandability and Peripheral Lipid Metabolism. PLoS Genetics. 2007 Apr 27;3(4):e64.

Medina-Gomez G, Virtue S, Lelliott C, Boiani R, Campbell M, Christodoulides C, Perrin C, Jimenez-Linan M, Blount M, Dixon J, Zahn D, Thresher RR, Aparicio S, Carlton M, Colledge WH, Kettunen MI, Seppanen-Laakso T, Sethi JK, O'Rahilly S, Brindle K, Cinti S, Oresic M, Burcelin R, Vidal-Puig A. The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform. Diabetes. 2005 Jun;54(6):1706-16.

Medina-Gomez G, Yetukuri L, Velagapudi V, Campbell M, Blount M, Jimenez-Linan M, Ros M, Oresic M, Vidal-Puig A. Adaptation and failure of pancreatic {beta} cells in murine models with different degrees of metabolic syndrome. Dis Model Mech. 2009 Oct 19.

Minehira K, Young SG, Villanueva CJ, Yetukuri L, Oresic M, Hellerstein MK, Farese RV Jr, Horton JD, Preitner F, Thorens B, Tappy L. Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. J Lipid Res. 2008 Sep;49(9):2038-44. Epub 2008 Jun 1.

Murakami T, Walczak R, Caron S, Duhem C, Vidal V, Darteil R, Staels B. The farnesoid X receptor induces fetuin-B gene expression in human hepatocytes. Biochem J. 2007 Jul 27; [Epub ahead of print].

Oosterveer MH, Grefhorst A, van Dijk TH, Havinga R, Staels B, Kuipers F, Groen AK, Reijngoud DJ. Fenofibrate simultaneously induces hepatic fatty acid oxidation, synthesis and elongation in mice. J Biol Chem. 2009 Oct 2. [Epub ahead of print]

Popescu IR, Helleboid-Chapman A, Lucas A, Vandewalle B, Dumont J, Bouchaert E, Derudas B, Kerr-Conte J, Caron S, Pattou F, Staels B. The nuclear receptor FXR is expressed in pancreatic b-cells and protects human islets from lipotoxicity. FEBS Lett. 2010 Jul 2;584(13):2845-51

Preitner F, Bonny O, Laverrière A, Rotman S, Firsov D, Da Costa A, Metref S, Thorens B. Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy. Proc Natl Acad Sci U S A. 2009 Aug 21. [Epub ahead of print]

Stroeve JH, Brufau G, Stellaard F, Gonzalez FJ, Staels B, Kuipers F.
Intestinal FXR-mediated FGF15 production contributes to diurnal control of hepatic bile acid synthesis in mice. Lab Invest. 2010 Jun 7. [Epub ahead of print]

van Dijk TH, Grefhorst A, Oosterveer MH, Bloks VW, Staels B, Reijngoud DJ, Kuipers F. An increased flux through the glucose 6-phosphate pool in enterocytes delays glucose absorption in FXR-/- mice. J Biol Chem. 2009 Apr;284(16):10315-23.

Yetukuri L, Katajamaa M, Medina-Gomez G, Seppänen-Laakso T, Vidal Puig A, Orešič M. Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis. BMC Systems Biology 1, e12 (2007). doi:10.1186/1752-0509-1-12.

Yetukuri L, Tikka J, Hollmén J, Oresic, M. Functional prediction of unidentified lipids using supervised classifiers. Metabolomics 2010 6: 18 – 26.

Human Studies: The Adipose - Liver Axis

Adiels M, Larsson T, Sutton P, Taskinen MR, Borén J, Fielding BA. Optimization of N-methyl-N-[tert-butyldimethylsilyl]trifluoroacetamide as a derivatization agent for determining isotopic enrichment of glycerol in very-low density lipoproteins. Rapid Commun. Mass Spectrom. 2010 Feb 8;24(5):586-592. [Epub ahead of print]

Adiels M, Westerbacka J, Soro-Paavonen A, Häkkinen AM, Vehkavaara S, Caslake MJ, Packard C, Olofsson SO, Yki-Järvinen H, Taskinen MR, Borén J. Acute suppression of VLDL(1) secretion rate by insulin is associated with hepatic fat content and insulin resistance. Diabetologia. 2007 Nov;50(11):2356-65. Epub 2007 Sep 12.

Anty R, Bekri S, Luciani N, Saint-Paul MC, Dahman M, Iannelli A, Amor IB, Staccini-Myx A, Huet PM, Gugenheim J, Sadoul JL, Le Marchand-Brustel Y, Tran A, Gual P. The Inflammatory C-Reactive Protein Is Increased in Both Liver and Adipose Tissue in Severely Obese Patients Independently from Metabolic Syndrome, Type 2 Diabetes, and NASH. Am J Gastroenterol. 2006 Aug;101(8):1824-33. Epub 2006 Jun 22.

Bekri S, Gual P, Anty R, Luciani N, Dahman M, Ramesh B, Iannelli A, Staccini-Myx A, Casanova D, Ben Amor I, Saint-Paul MC, Huet PM, Sadoul JL, Gugenheim J, Srai SK, Tran A, Le Marchand-Brustel Y. Increased Adipose Tissue Expression of Hepcidin in Severe Obesity Is Independent From Diabetes and NASH. Gastroenterology. 2006 Sep;131(3):788-796.

Borra R, Lautamäki R, Parkkola R, Komu M, Sijens PE, Hällsten K, Bergman J, Iozzo P, Nuutila P. Inverse association between liver fat content and hepatic glucose uptake in patients with type 2 diabetes mellitus. Metabolism. 2008 Oct;57(10):1445-51.

Chong MF, Hodson L, Bickerton AS, Roberts R, Neville M, Karpe F, Frayn KN, Fielding BA. Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding. Am J Clin Nutr. 2008 Apr;87(4):817-23.

Di Marzo V, Verrijken A, Hakkarainen A, Petrosino S, Mertens I, Lundbom N, Piscitelli F, Westerbacka J, Soro-Paavonen A, Matias I, van Gaal L, Taskinen M-R. Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects. European Journal of Endocrinology 2009;Aug (Sep 10. [Epub ahead of print])

Greco D, Kotronen A, Westerbacka J, Puig O, Arkkila P, Kiviluoto T, Laitinen S, Kolak M, Fisher RM, Hamsten A, Auvinen P, Yki-Järvinen H. Gene expression in human NAFLD. Am J Physiol Gastrointest Liver Physiol. 2008 May;294(5):G1281-7. Epub 2008 Apr 3.

Guiducci L, Gronroos T, Jarvisalo MJ, Kiss J, Viljanen A, Naum AG, Viljanen T, Savunen T, Knuuti J, Ferrannini E, Salvadori PA, Nuutila P, Iozzo P. Biodistribution of the fatty acid analogue 18F-FTHA: plasma and tissue partitioning between lipid pools during fasting and hyperinsulinemia. J Nucl Med. 2007 Mar;48(3):455-62.

Guiducci L, Jarvisalo M, Kiss J, Nagren K, Viljanen A, Naum AG, Gastadelli A, Savunen T, Knuuti J, Salvadori PA, Ferrannini E, Nuutila P, Iozzo P. [11C]palmitate kinetics across the splanchnic bed in arterial, portal and hepatic venous plasma during fasting and euglycemic hyperinsulinemia. Nucl Med Biol. 2006 May;33(4):521-8. Epub 2006 May 2.

Hodson L, Bickerton AS, McQuaid SE, Roberts R, Karpe F, Frayn KN, Fielding BA. The contribution of splanchnic fat to VLDL triglyceride is greater in insulin-resistant than insulin-sensitive men and women: studies in the postprandial state. Diabetes. 2007 Oct;56(10):2433-41. Epub 2007 Jun 29.

Hodson L, McQuaid SE, Humphreys SM, Milne R, Fielding B, Frayn KN, Karpe F. Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation? Am J Physiol Endocrinol Metab 2010 Oct;299(4):E584-92. Epub 2010 Jul 13.

Iozzo P, Gastaldelli A, Jarvisalo MJ, Kiss J, Borra R, Buzzigoli E, Viljanen A, Naum G, Viljanen T, Oikonen V, Knuuti J, Savunen T, Salvadori PA, Ferrannini E, Nuutila P. 18F-FDG assessment of glucose disposal and production rates during fasting and insulin stimulation: a validation study. J Nucl Med. 2006 Jun;47(6):1016-22.

Iozzo P, Jarvisalo MJ, Kiss J, Borra R, Naum GA, Viljanen A, Viljanen T, Gastaldelli A, Buzzigoli E, Guiducci L, Barsotti E, Savunen T, Knuuti J, Haaparanta-Solin M, Ferrannini E, Nuutila P. Quantification of liver glucose metabolism by positron emission tomography: validation study in pigs. Gastroenterology. 2007 Feb;132(2):531-42. Epub 2006 Dec 21.

Iozzo P, Lautamaki R, Borra R, Lehto HR, Bucci M, Viljanen A, Parkka J, Lepomaki V, Maggio R, Parkkola R, Knuuti J, Nuutila P. Contribution of glucose tolerance and gender to cardiac adiposity. J Clin Endocrinol Metab. 2009 Nov;94(11):4472-82. Epub 2009 Oct 9.

Iozzo P, Bucci M, Roivainen A, Någren K, Järvisalo MJ, Kiss J, Guiducci L, Fielding B, Naum AG, Borra R, Virtanen K, Savunen T, Salvadori PA, Ferrannini E, Knuuti J, Nuutila P. Faty Acid Metabolism in the Liver, Measured by Pisitron Emission Tomography, Is Increased in Obese Individuals. Gastroenterology 2010;139:846-856

Juurinen L, Kotronen A, Granér M, Yki-Järvinen H. Rosiglitazone reduces liver fat and insulin requirements and improves hepatic insulin sensitivity and glycemic control in patients with type 2 diabetes requiring high insulin doses. J Clin Endocrinol Metab. 2008 Jan;93(1):118-24. Epub 2007 Oct 23.

Kankaanpää M, Lehto HR, Pärkkä JP, Komu M, Viljanen A, Ferrannini E, Knuuti J, Nuutila P, Parkkola R, Iozzo P. Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels. J Clin Endocrinol Metab. 2006 Nov;91(11):4689-95. Epub 2006 Aug 22.

Karmi A, Iozzo P, Viljanen A, Hirvonen J, Fielding B, Virtanen K, Oikonen V, Kemppainen J, Viljanen T, Guiducci L, Haaparanta-Solin M, Någren K, Solin O, Nuutila P
. Increased Brain Fatty Acid Uptake in Metabolic Syndrome. Diabetes 2010;59:2171-2177.

Kolak M, Westerbacka J, Velagapudi VR, Wågsäter D, Yetukuri L, Makkonen J, Rissanen A, Häkkinen A-M, Lindell M, Bergholm R, Hamsten A, Eriksson P, Fisher RM, Orešic M, Yki-Järvinen H. Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat independent of obesity. Diabetes. 2007 Aug;56(8):1960-8. Epub 2007 Jul 9. PMID: 17620421 [PubMed - as supplied by publisher].

Kotronen A, Joutsi-Korhonen L, Sevastianova K, Bergholm R, Hakkarainen A, Pietiläinen KH, Lundbom N, Rissanen A, Lassila R, Yki-Järvinen H. Increased coagulation factor VIII, IX, XI and XII activities in non-alcoholic fatty liver disease. Liver Int. 2011 Feb;31(2):176-183. Epub 2010 Dec 7.

Kotronen A, Yki-Järvinen H, Sevastianova K, Bergholm R, Hakkarainen A, Pietiläinen KH, Juurinen L, Lundbom N, Sørensen TI. Comparison of Relative Contributions of the Intra-Abdominal and Liver Fat to Components of the Metabolic Syndrome. Obesity 2010 June 10 [Epub ahead of print]

Kotronen A, Yki-Järvnen H, Männistö S, Saarikoski L, Korpi-Hyövälti E, Oksa H, Saltevo T, Sundvall J, Tuomilehto J, Peltonen M. Non-alcoholic and alcoholic fatty liver disease - two diseases of affluence associated with the metabolic syndrome and type 2 diabetes: the FIN-D2D survey. BMC Public Health. 2010 May 10;10:237.

Kotronen A, Johansson LE, Johansson LM, Roos C, Westerbacka J, Hamsten A, Bergholm R, Arkkila P, Arola J, Kiviluoto T, Fisher RM, Ehrenborg E, Orho-Melander M, Ridderstråle M, Groop L, Yki-Järvinen H. A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans. Diabetologia. 2009 Jun;52(6):1056-60.

Kotronen A, Juurinen L, Hakkarainen A, Westerbacka J, Cornér A, Bergholm R, Yki-Järvinen H. Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects. Diabetes Care. 2008 Jan;31(1):165-9. Epub 2007 Oct 12.

Kotronen A, Juurinen L, Tiikkainen M, Vehkavaara S, Yki-Järvinen H. Increased Liver Fat, Impaired Insulin Clearance, and Hepatic and Adipose Tissue Insulin Resistance in Type 2 Diabetes. Gastroenterology. 2008 Mar 21. [Epub ahead of print]

Kotronen A, Lewitt M, Hall K, Brismar K, Yki-Järvinen H. Insulin-like growth factor binding protein 1 as a novel specific marker of hepatic insulin sensitivity. J Clin Endocrinol Metab. 2008 Sep 16. [Epub ahead of print]

Kotronen A, Peltonen M, Hakkarainen A, Sevastianova K, Bergholm R, Johansson LM, Lundbom N, Rissanen A, Ridderstråle M, Groop L, Orho-Melander M, Yki-Järvinen H. Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors. Gastroenterology. 2009 Sep;137(3):865-72.

Kotronen A, Seppälä-Lindroos A, Bergholm R, Yki-Järvinen H. Tissue specificity of insulin resistance in humans: fat in the liver rather than muscle is associated with features of the metabolic syndrome. Diabetologia. 2008 Jan;51(1):130-8. Epub 2007 Nov 16.

Kotronen A, Seppälä-Lindroos A, Vehkavaara S, Bergholm R, Frayn KN, Fielding BA, Yki-Järvinen H. Liver fat and lipid oxidation in humans. Liver Int. 2009 Oct;29(9):1439-46.

Kotronen A, Seppänen-Laakso T, Westerbacka J, Kiviluoto T, Arola JT, Ruskeepää AL, Oresic M, Yki-Järvinen H. Hepatic SCD1 activity and diacylglycerol but not ceramide concentrations are increased in the non-alcoholic human fatty liver. Diabetes. 2009 Jan;58(1):203-8.

Kotronen A, Seppänen-Laakso T, Westerbacka J, Kiviluoto T, Arola J, Ruskeepää AL, Yki-Järvinen H, Orešič M. Comparison of Lipid and Fatty Acid Composition of the Liver, Subcutaneous and Intra-abdominal Adipose Tissue, and Serum. Obesity (Silver Spring). 2009 Oct 1. [Epub ahead of print]

Kotronen A, Vehkavaara S, Seppälä-Lindroos A, Bergholm R, Yki-Järvinen H. Effect of liver fat on insulin clearance. Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1709-15. Epub 2007 Sep 25.

Kotronen A, Velagapudi VR, Yetukuri L, Westerbacka J, Bergholm R, Ekroos K, Makkonen J, Taskinen MR, Orešič M, Yki-Järvinen H. Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations. Diabetologia. 2009 Apr;52(4):684-90.

Kotronen A, Westerbacka J, Bergholm R, Pietilainen KH, Yki-Jarvinen H. Liver fat in the metabolic syndrome. J Clin Endocrinol Metab. 2007 Sep;92(9):3490-7.

Kotronen A, Yki-Jarvinen H, Aminoff A, Bergholm R, Pietilainen K, Westerbacka J, Talmud P, Humphries S, Hamsten A, Isomaa B, Groop L, Orho-Melander M, Ehrenborg E, Fisher R. Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts. Eur J Endocrinol. 2009 Apr;160(4):593-602.

Lundbom J, Heikkinen S, Fielding B, Hakkarainen A, Taskinen M-R, Lundbom N. PRESS echo time behavior of triglyceride resonances at 1.5 Tesla: Detecting omega-3 fatty acids in adipose tissue in vivo. Journal of Magnetic Resonance. Accepted 2009;Jul. (Aug 3. [Epub ahead of print])

Lundbom J, Hakkarainen A, Söderlund S, Westerbacka J, Taskinen M-R, Lundbom N. Long echo time 1H-MRS suggests liver fat is more saturated than subcutaneous and visceral fat. NMR in Biomedicine Article first published online: 6 SEP 2010

Lundbom J, Hakkarainen A, Fielding B, Söderlund S, Westerbacka J, Taskinen MR, Lundbom N. Characterizing human adipose tissue lipids by long echo time 1H-MRS in vivo at 1.5 Tesla: validation by gas chromatography. NMR Biomed. 23(5):466-472, 2010.

Makkonen J, Westerbacka J, Kolak M, Sutinen J, Corner A, Hamsten A, Fisher RM, Yki-Jarvinen H. Increased expression of the macrophage markers and of 11beta-HSD-1 in subcutaneous adipose tissue, but not in cultured monocyte-derived macrophages, is associated with liver fat in human obesity. Int J Obes (Lond). 2007 Apr 24; [Epub ahead of print].

Matikainen N, Manttari S, Westerbacka J, Vehkavaara S, Lundbom N, Yki-Jarvinen H, Taskinen MR. Postprandial lipemia associates with liver fat content. J Clin Endocrinol Metab. 2007 Aug;92(8):3052-9. Epub 2007 May 8.

Moren X, Deakin S, Liu ML, Taskinen MR, James RW. HDL subfraction distribution of paraoxonase-1 and its relevance to enzyme activity and resistance to oxidative stress. J Lipid Res. 2008 Jun;49(6):1246-53.

Miller NE, Michel CC, Nanjee MN, Olszewski WL, Miller IP, Hazell M, Olivecrona G, Sutton P, Humphreys SM, Frayn KN. Secretion of adipokines by human adipose tissue in vivo: partitioning between capillary and lymphatic transport. Am J Physiol Endocrinol Metab 301:E659-E667, 2011. First published 12 July 2011.

Pietiläinen KH, Róg T, Seppänen-Laakso T, Virtue S, Gopalacharyulu P, Tang J, Rodriguez-Cuenca S, Maciejewski A, Naukkarinen J, Ruskeepää AL, Niem elä PS, Yetukuri L, Tan CY, Velagapudi V, Castillo S, Nygren H, Hyötyläinen T, Rissanen A, Kaprio J, Yki-Järvinen H, Vattulainen I, Vidal-Puig A, Orešič M. Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans. PLoS Biol. 2011 Jun;9(6):

Rigazio S, Lehto HR, Tuunanen H, Någren K, Kankaanpaa M, Simi C, Borra R, Naum AG, Parkkola R, Knuuti J, Nuutila P, Iozzo P. The lowering of hepatic fatty acid uptake improves liver function and insulin sensitivity without affecting hepatic fat content in humans. Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E413-9. Epub 2008 May 27. PMID: 18505832 [PubMed - indexed for MEDLINE]

Sevastianova K, Hakkarainen A, Kotronen A, Cornér A, Arkkila P, Arola J, Westerbacka J, Bergholm R, Lundbom J, Lundbom N, Yki-Järvinen H. Nonalcoholic fatty liver disease: detection of elevated nicotinamide
adenine dinucleotide phosphate with in vivo 3.0-T 31P MR spectroscopy with proton decoupling. Radiology. 2010 Aug;256(2):466-73.

Simonen P, Kotronen A, Hallikainen M, Sevastianova K, Makkonen J, Hakkarainen A, Lundblom N, Miettinen T, Gylling H, Yki-Järvinen H. Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity. Journal of Hepatology 2011 vol. 54 j 153–159

Slimani L, Oikonen V, Hallsten K, Savisto N, Knuuti J, Nuutila P, Iozzo P. Exercise restores skeletal muscle glucose delivery but not insulin-mediated glucose transport and phosphorylation in obese subjects. J Clin Endocrinol Metab. 2006 Jun 13; [Epub ahead of print].

Sysi-Aho M, Vehtari A, Velagapudi VR, Westerbacka J, Yetukuri L, Bergholm R, Taskinen MR, Yki-Jarvinen H, Oresic M. Exploring the lipoprotein composition using Bayesian regression on serum lipidomic profiles. Bioinformatics. 2007 Jul 1;23(13):i519-28.

Tolonen N, Forsblom C, Thorn L, Wadén J, Rosengård-Bärlund M, Saraheimo M, Heikkilä O, Pettersson-Fernholm K, Taskinen MR, Groop PH; FinnDiane Study Group. Relationship between lipid profiles and kidney function in patients with type 1 diabetes. Diabetologia. 2008 Jan;51(1):12-20.

Tordjman J, Poitou C, Hugol D, Bouillot JL, Basdevant A, Bedossa P, Guerre-Millo M, Clement K. Association between omental adipose tissue macrophages and liver histopathology in morbid obesity: Influence of glycemic status. J Hepatol. 2009 Aug;51(2):354-62. Epub 2009 Apr 24.

Tussing-Humphries L, Frayn KN, Smith SR, Westerman M, Dennis L, Nemeth E, Thomson J, Pusatcioglu C. Subcutaneous Adipose Tissue from Obese and LeanAdults Does Not Release Hepcidin In Vivo

Tran C, Jacot-Descombes D, Lecoultre V, Fielding B, Carrel G, Le k, Schneiter P, Bortolotti M, Frayn KN, Tappy L. Sex differences in lipid and glucose kinetics after ingestion of an acute oral fructose load. Br J Nutr 2010 Oct;104(8):1139-47. Epub 2010 Jun 14.

Vanni E, Bugianesi E, Kotronen A, De Minicis S, Yki-Järvinen H, Svegliati-Baroni G. From the metabolic syndrome to NAFLD or vice versa? Digestive and Liver Diseases 2010;42: 320-330.

Viljanen AP, Iozzo P, Borra R, Kankaanpää M, Karmi A, Lautamäki R, Järvisalo M, Parkkola R, Rönnemaa T, Guiducci L, Lehtimäki T, Raitakari OT, Mari A, Nuutila P. Effect of Weight Loss on Liver Free Fatty Acid Uptake and Hepatic Insulin Resistance. J Clin Endocrinol Metab. 2008 Oct 28. [Epub ahead of print] PMID: 18957499 [PubMed - as supplied by publisher]

Viljanen AP, Lautamaki R, Jarvisalo M, Parkkola R, Huupponen R, Lehtimaki T, Ronnemaa T, Raitakari OT, Iozzo P, Nuutila P. Effects of weight loss on visceral and abdominal subcutaneous adipose tissue blood-flow and insulin-mediated glucose uptake in healthy obese subjects. Ann Med. 2008 Oct 14:1-9. [Epub ahead of print] PMID: 18855190 [PubMed - as supplied by publisher]

Westerbacka J, Kotronen A, Fielding BA, Wahren J, Hodson L, Perttilä J, Seppänenlaakso T, Suortti T, Arola J, Hultcrantz R, Castillo S, Olkkonen VM, Frayn KN, Orešič M,Yki- Järvinen H. Splanchnic Balance of Free Fatty Acids, Endocannabinoids, and Lipids in Subjects With Nonalcoholic Fatty Liver Disease. Gastroenterology. 2010 Jun 27. [Epub ahead of print]

Yetukuri L, Söderlund S, Koivuniemi A, Seppänen-Laakso T, Niemelä PS, Hyvönen M, Taskinen M-R,Vattulainen, I, Jauhiainen M, Orešič M. Composition and lipid spatial distribution of High Density Lipoprotein particles in subjects with low and high HDL-cholesterol. J Lipid Res 51;8:2341-2351, 2010.

Clinical and Genetic Epidemiological Studies

Andersen G, Burgdorf KS, Sparsø T, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O. AHSG tag single nucleotide polymorphisms associate with type 2 diabetes and dyslipidemia: studies of metabolic traits in 7,683 white Danish subjects. Diabetes. 2008 May;57(5):1427-32.

Andreasen CH, Mogensen MS, Borch-Johnsen K, Sandbæk A, Lauritzen T, Almind K, Hansen L, Jørgensen T, Pedersen O, Hansen T. Studies of CTNNBL1 and FDFT1 variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes. BMC Med. Genet. 2009; 10: 17.

Andreasen CH, Mogensen MS, Borch-Johnsen K, Sandbaek A, Lauritzen T, Sørensen TI, Hansen L, Almind K, Jørgensen T, Pedersen O, Hansen T. Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes. PLoS ONE 2008;3:e2872.

Andreasen CH, Stender-Petersen KL, Mogensen MS, Torekov SS, Wegner L, Andersen G, Nielsen AL, Albrechtsen A, Borch-Johnsen K, Rasmussen SS, Clausen JO, Sandbaek A, Lauritzen T, Hansen L, Jørgensen T, Pedersen O, Hansen T. Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes. 2008 Jan;57(1):95-101.

Auro K, Kristiansson K, Zethelius B, Berne C, Lannfelt L, Taskinen MR, Jauhiainen M, Perola M, Peltonen L, Syvänen AC. USF1 gene variants contribute to metabolic traits in men in a longitudinal 32-year follow-up study. Diabetologia. 2008 Mar;51(3):464-72.

Berentzen T, Jakobsen MU, Halkjaer J, Tjønneland A, Overvad K, Sørensen TIA. Changes in waist circumference and mortality in middle-aged men and women. PLoS One 2010 Sep 30;5(9).

Berentzen T, Kring SI, Holst C, Zimmermann E, Jess T, Hansen T, Pedersen O, Toubro S, Astrup A, Sørensen TI. Lack of association of fatness-related FTO gene variants with energy expenditure or physical activity. J Clin Endocrin & Metab 2008;93:2904-2908.

Boesgaard TW, Castella SI, Andersen G, Albrechtsen A, Sparsø T, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O. A -243A-->G polymorphism upstream of the gene encoding GAD65 associates with lower levels of body mass index and glycaemia in a population-based sample of 5857 middle-aged White subjects. Diabet Med. 2007 Jul;24(7):702-6. Epub 2007 Apr 24.

Francque S, Verrijken A, Mertens I, Hubens G, Van Marck E, Pelckmans P, Michielsen P, Van Gaal L. Visceral adiposity and insulin resistance are independent predictors of the presence of non-cirrhotic NAFLD-related portal hypertension. Int J Obes (Lond). 2010 Jul 27. [Epub ahead of print]

Francque S, Verrijken A, Mertens I, et al., Non-cirrhotic human NAFLD induces portal hypertension in relation to the histological degree of steatosis, Eur J Gastroenterol Hepatol, 2010; Eur J Gastroenterol Hepatol, 2010;22:1449-57.

Gjesing AP, Larsen LH, Torekov SS, Hainerová IA, Kapur R, Johansen A, Albrechtsen A, Boj S, Holst B, Harper A, Urhammer SA, Borch Johnsen K, Pisinger C, Echwald SM, Eiberg H, Astrup A, Lebl J, Ferrer J, Schwartz TW, Hansen T, Pedersen O. Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity. PLoS One 2010; 5(4): e10084.

Grarup N, Andreasen CH, Andersen MK, Albrechtsen A, Sandbaek A, Lauritzen T, Borch-Johnsen K, Jørgensen T, Schmitz O, Hansen T, Pedersen O. The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects. J Clin Endocrinol Metab. 2008 Jun;93(6):2294-9.

Grarup N, Stender-Petersen KL, Andersson EA, Jørgensen T, Borch-Johnsen K, Sandbaek A, Lauritzen T, Schmitz O, Hansen T, Pedersen O. Association of variants in the sterol regulatory element-binding factor 1 (SREBF1) gene with type 2 diabetes, glycemia, and insulin resistance: a study of 15,734 Danish subjects.Diabetes. 2008 Apr;57(4):1136-42.

Huertas-Vazquez A, Plaisier C, Weissglas-Volkov D, Sinsheimer J, Canizales-Quinteros S, Cruz-Bautista I, Nikkola E, Herrera-Hernandez M, Davila-Cervantes A, Tusie-Luna T, Taskinen MR, Aguilar-Salinas C, Pajukanta P. TCF7L2 is associated with high serum triacylglycerol and differentially expressed in adipose tissue in families with familial combined hyperlipidaemia. Diabetologia. 2008 Jan;51(1):62-9.

Jakobsen MU, Overvad K.
Macronutrient advice for ischemic heart disease prevention. Curr Opin Lipidol 2010. [Epub ahead of print]

Jakobsen MU, Dethlefsen C, Joensen AM, Stegger J, Tjønneland A, Schmidt EB, Overvad K. Intake of carbohydrates compared with intake of saturated fatty acids and risk of myocardial infarction: importance of the glycemic index. Am J Clin Nutr 2010;91:1764-8.

Jensen DP, Andreasen CH, Andersen MK, Hansen L, Eiberg H, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O. The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites. J Mol Med. 2007 May;85(5):445-9. Epub 2007 Jan 10.

Kathiresan S, Melander O, Guiducci C, Surti A, Burtt NP, Rieder MJ, Cooper GM, Roos C, Voight BF, Havulinna AS, Wahlstrand B, Hedner T, Corella D, Tai ES, Ordovas JM, Berglund G, Vartiainen E, Jousilahti P, Hedblad B, Taskinen MR, Newton-Cheh C, Salomaa V, Peltonen L, Groop L, Altshuler DM, Orho-Melander M. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet. 2008 Feb;40(2):189-97.

Kring SI, Holst C, Toubro S, Astrup A, Hansen T, Pedersen O, Sørensen TI. Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure. Int J Obes 2009, Oct 20. [Epub ahead of print]

Kring SI, Holst C, Zimmermann E, Jess T, Berentzen T, Toubro S, Hansen T, Astrup A, Pedersen O, Sørensen TI. FTO gene associated fatness in relation to body fat distribution and metabolic traits throughout a broad range of fatness. PLoS ONE. 2008 Aug 13;3(8):e2958.

Kring SII, Larsen LH, Holst C, Toubro S, Hansen T, Astrup A, Pedersen O, Sørensen TIAS. Genotype-Phenotype Associations in Obesity Dependent on Definition of the Obesity Phenotype. Obesity Facts 2008;1:138-145.

Kring SI, Werge T, Holst C, Toubro S, Astrup A, Hansen T, Pedersen O, Sørensen TI. Polymorphisms of serotonin receptor 2A and 2C genes and COMT in relation to obesity and type 2 diabetes. PLoS ONE 2009;4:e6696.

Romaguera D, Angquist L, Du H, Jakobsen MU, Forouhi NG, Halkjaer J, Feskens EJ, van der A DL, Masala G, Steffen A, Palli D, Wareham NJ, Overvad K, Tjønneland A, Boeing H, Riboli E, Sørensen TI. Dietary determinants of changes in waist circumference adjusted for body mass index - a proxy measure of visceral adiposity. PLoS One 2010;5:e11588.

Severinsen MT, Overvad K, Johnsen SP, Dethlefsen C, Madsen PH, Tjønneland A, Kristensen SR. Genetic susceptibility, smoking, obesity and risk of venous thromboembolism. Br J Haematol 2010;149:273-9.

Sparsø T, Andersen G, Nielsen T, Burgdorf KS, Gjesing AP, Nielsen AL, Albrechtsen A, Rasmussen SS, Jørgensen T, Borch-Johnsen K, Sandbaek A, Lauritzen T, Madsbad S, Hansen T, Pedersen O. The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes. Diabetologia. 2008 Jan;51(1):70-5.

Sparsø T, Hussain MS, Andersen G, Hainerova I, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O. Relationships between the functional PPARalpha Leu162Val polymorphism and obesity, type 2 diabetes, dyslipidaemia, and related quantitative traits in studies of 5799 middle-aged white people. Mol Genet Metab. 2007 Feb;90(2):205-9. Epub 2006 Nov 28.

Verrijken A, Francque S, Mertens I, Talloen M, Peiffer F, Van Gaal L. Visceral adipose tissue and inflammation correlate with elevated liver tests in a cohort of overweight and obese pateins. Int J Obes (Lond). 2010 May;34(5):899-907.

Zimmermann E, Kring SI, Berentzen TL, Holst C, Pers TH, Hansen T, Pedersen O, Sørensen TI, Jess T. Fatness-associated FTO gene variant increases mortality independent of fatness--in cohorts of Danish men. PLoS One 2009;4:e4428.

Zobel DP, Andreasen CH, Grarup N, Eiberg H, Sørensen TI, Sandbaek A, Lauritzen T, Borch-Johnsen K, Jørgensen T, Pedersen O, Hansen T. Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes. Diabetes 2009;58:757-764.

Integration and Development of Omics and Bioinformatics

Prifti E, Zucker JD, Clement K, Henegar C. FunNet: an integrative tool for exploring transcriptional interactions. Bioinformatics. 2008 Sep 17. [Epub ahead of print]

Prifti E, Zucker J, Clément K, Henegar1 C
. Interactional and functional centrality in transcriptional co-expression networks. Bioinformatics. 2010 Dec 15;26(24):3083-9. Epub 2010 Oct 19.

Poussin C, Hall D, Minehira K, Galzin A-M, Tarussio D, Thorens B. Different Transcriptional Control of Metabolism and Extracellular Matrix in Visceral and Subcutaneous Fat of Obese and Rimonabant Treated Mice. PLoS ONE 3(10): e3385. doi:10.1371/journal.pone.0003385.

Coordinator: T.I.A. Sørensen, Institute of Preventive Medicine - Web editor: Louise Thers Nielsen